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Invitrogen
ERH Polyclonal Antibody
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Product Details
PA5-51723
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ERH. Recombinant protein control fragment (Product #RP-89033).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LVQPTKRPEG RTYADYESVN ECMEGVCKMY EEHLKRMNPN SPSITYDISQ LFDFIDDLAD LSCLVYRADT QTYQPYNKDW IKEKIYVLLR RQAQQAGK
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
The Enhancer of Rudimentary Homolog (ERH) is a highly conserved protein with significant roles in the regulation of gene expression and cell cycle control. Structurally, ERH forms homodimers, characterized by a crystal structure resolving at 2.0 A, which reveals its ability to bind specific protein regions via a hydrophobic groove. Functionally, ERH interacts with various cellular components, notably integrating into the Microprocessor complex where it facilitates microRNA maturation by binding with the N-terminus of DGCR8 at a 2:2 stoichiometry. This interaction underscores ERH's role in gene silencing, contributing to the biogenesis of small interfering RNAs (siRNAs). Additionally, ERH is implicated in transcriptional regulation and has been associated with DNA replication, suggesting its involvement in broader genomic functions. Despite its diverse roles, ERH operates in a plug-and-play manner, allowing its interaction with different cellular factors to fulfill pleiotropic functions across metazoans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Enhancer of rudimentary homolog; Mer; preimplantation protein 1
Gene Aliases: DROER; ERH; Mer; Prei1
UniProt ID: (Human) P84090, (Mouse) P84089
Entrez Gene ID: (Human) 2079, (Rat) 681415, (Mouse) 13877
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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