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Invitrogen
PKN1 Polyclonal Antibody
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Product Details
PA5-52036
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PKN1. Recombinant protein control fragment (Product #RP-102277).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QKLGLLREAL ERRLGELPAD HPKGRLLREE LAAASSAAFS TRLAGPFPAT HYSTLCKPAP LTGTLEVRVV GCRDLPETIP WNPTPSMGGP GTPDSRPPFL SRPARGLYSR SGSLSGRSSL KAEAENTSEV S
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 86%.
Target Information
PKN1 (PRK1) belongs to the protein kinase C superfamily. This kinase is activated by the Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can also be activated by phospholipids. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PAK-1; Protease-activated kinase 1; Protein kinase C-like 1; Protein kinase C-like PKN; protein kinase C-related kinase 1; protein kinase PKN; Protein kinase PKN-alpha; Protein-kinase C-related kinase 1; serine-threonine kinase N; Serine-threonine protein kinase N; serine/threonine kinase 3; serine/threonine protein kinase N; Serine/threonine-protein kinase N1; unnamed protein product
Gene Aliases: DBK; F730027O18Rik; PAK-1; PAK1; PKN; PKN-ALPHA; PKN1; PRK1; PRKCL1; Stk3
UniProt ID: (Human) Q16512, (Rat) Q63433, (Mouse) P70268
Entrez Gene ID: (Human) 5585, (Rat) 29355, (Mouse) 320795
nucleotide binding
chromatin binding
transcription coactivator activity
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
protein kinase C binding
protein binding
ATP binding
kinase activity
transferase activity
small GTPase binding
histone kinase activity (H3-T11 specific)
histone binding
histone deacetylase binding
androgen receptor binding
protein serine kinase activity
GTP-Rho binding
ligand-dependent nuclear receptor transcription coactivator activity
Rac GTPase binding
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
B cell homeostasis
B cell apoptotic process
regulation of germinal center formation
regulation of immunoglobulin production
renal system process
chromatin organization
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
hyperosmotic response
signal transduction
epithelial cell migration
negative regulation of B cell proliferation
intracellular signal transduction
post-translational protein modification
positive regulation of transcription, DNA-templated
spleen development
regulation of androgen receptor signaling pathway
regulation of cell motility
negative regulation of protein phosphorylation
transcription, DNA-templated
negative regulation of protein kinase activity
histone H3-T11 phosphorylation
regulation of transcription, DNA-templated
phosphorylation
chromatin modification
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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