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Invitrogen
TPM3 Polyclonal Antibody
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Product Details
PA5-52644
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TPM3. Recombinant protein control fragment (Product #RP-89192).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AERLQREVEG ERRAREQAEA EVASLNRRIQ LVEEELDRAQ ERLATALQKL EEAEKAADES ERGMKVIENR ALKDEEKMEL QEIQLKEAKH IAEEADRKYE EVARKLVIIE GDLERTEERA ELAESRCREM DEQIRLMDQN LKCLSA
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
TPM3 (tropomyosin 3) is a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha-tropomyosin, slow skeletal; cytoskeletal tropomyosin TM30; epididymis luminal protein 189; epididymis secretory sperm binding protein Li 82p; Gamma-tropomyosin; heat-stable cytoskeletal protein 30 kDa; hTM5; nonmuscle tropomyosin 5; skalphaTM.2; tropomyosin; tropomyosin 3, gamma; tropomyosin 5; Tropomyosin alpha-3 chain; tropomyosin gamma; tropomyosin non-muscle; Tropomyosin-3; Tropomyosin-5
Gene Aliases: CAPM1; CFTD; gamma-TM; HEL-189; HEL-S-82p; hscp30; hTM30nm; hTMnm; NEM1; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TM5; Tm5NM; TMnm; Tpm-5; TPM3; Tpm5; TPMsk3; TRK; Trop-5
UniProt ID: (Human) P06753, (Rat) Q63610, (Mouse) P21107
Entrez Gene ID: (Human) 7170, (Rat) 117557, (Mouse) 59069
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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