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Invitrogen
MARCH1 Polyclonal Antibody
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Product Details
PA5-53199
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MARCH1. Recombinant protein control fragment (Product #RP-90986).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KVYVQLWRRL KAYNRVIFVQ NCPDTAKKLE KNFSCNVNTD IKDAVVVPVP QTGANSLPSA EGG
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 87%.
Target Information
E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 1-Mar; E3 ubiquitin-protein ligase MARCH1; E3 ubiquitin-protein ligase MARCHF1; MARCH-I; membrane associated ring finger 1; membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase; Membrane-associated RING finger protein 1; Membrane-associated RING-CH protein I; RING finger protein 171; RING-type E3 ubiquitin transferase MARCH1; RING-type E3 ubiquitin transferase MARCHF1; unnamed protein product
Gene Aliases: MARCH-I; MARCH1; MARCHF1; RNF171
UniProt ID: (Human) Q8TCQ1
Entrez Gene ID: (Human) 55016
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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