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Invitrogen
SP100 Polyclonal Antibody
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Product Details
PA5-53602
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SP100. Recombinant protein control fragment (Product #RP-91588).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YKGFENVIHD KLPLQESEEE EREERSGLQL SLEQGTGENS FRSLTWPPSG SPSHAGTTPP ENGLSEHPCE TEQINAKRKD TTSDKDDSLG SQQTNEQCAQ KAEPTESCEQ IAVQVNNGDA GREMPCPL
Highest antigen sequence identity to the following orthologs: Mouse - 24%, Rat - 24%.
Target Information
This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686E07254; FLJ00340; FLJ34579; nuclear autoantigen; Nuclear autoantigen Sp-100; Nuclear dot-associated Sp100 protein; SP 100; SP100-HMG nuclear autoantigen; Speckled 100 kDa; splice variant; unnamed protein product
Gene Aliases: lysp100b; SP100
UniProt ID: (Human) P23497
Entrez Gene ID: (Human) 6672
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription corepressor activity
protein binding
kinase binding
protein domain specific binding
identical protein binding
protein homodimerization activity
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
chromo shadow domain binding
negative regulation of transcription from RNA polymerase II promoter
telomere maintenance
DNA metabolic process
regulation of transcription from RNA polymerase II promoter
defense response
immune response
negative regulation of endothelial cell migration
DNA damage response, signal transduction by p53 class mediator
response to retinoic acid
negative regulation of viral transcription
response to cytokine
response to type I interferon
response to interferon-gamma
maintenance of protein location
regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of protein export from nucleus
retinoic acid receptor signaling pathway
regulation of viral process
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of Fas signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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