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Invitrogen
RAD21 Polyclonal Antibody
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Product Details
PA5-54128
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RAD21. Recombinant protein control fragment (Product #RP-101037).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KLMMWKETGG VEKLFSLPAQ PLWNNRLLKL FTRCLTPLVP EDLRKRRKGG EADNLDEFLK EFENPEVPRE DQQQQHQQRD VIDEPIIEEP SRLQESVMEA SRTNIDESAM PPPPPQGVKR KAGQIDPEPV MPPQQVEQME IPPVEL
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 92%.
Target Information
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Double-strand-break repair protein rad21 homolog; FLJ25655; FLJ40596; h NXP-1; hHR21; KIAA0078RAD21; kleisin; Nuclear matrix protein 1; NXP-1; protein involved in DNA double-strand break repair; RAD21 homolog; SCC1 homolog; sister chromatid cohesion 1
Gene Aliases: CDLS4; hHR21; HR21; HRAD21; KIAA0078; MCD1; NXP1; RAD21; SCC1
UniProt ID: (Human) O60216
Entrez Gene ID: (Human) 5885
double-strand break repair
DNA recombination
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
apoptotic process
sister chromatid cohesion
mitotic nuclear division
reciprocal meiotic recombination
protein sumoylation
positive regulation of transcription from RNA polymerase II promoter
cell division
protein localization to chromatin
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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