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Invitrogen
ALOX12B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-54949
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ALOX12B. Recombinant protein control fragment (Product #RP-93477).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LYKLLIPHTR YTVQINSIGR AVLLNEGGLS AKGMSLGVEG FAGVMVRALS ELTYDSLYLP NDFVERGVQD LPGYYYRDDS LAVWNALEKY VTEI
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 84%.
Target Information
This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 12R-lipoxygenase; epidermis-type lipoxygenase 12
Gene Aliases: 12R-LOX; ARCI2
UniProt ID: (Human) O75342
Entrez Gene ID: (Human) 242
arachidonate 12-lipoxygenase activity
iron ion binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
metal ion binding
arachidonate 8(R)-lipoxygenase activity
arachidonate 12(R)-lipoxygenase activity
linoleate 9S-lipoxygenase activity
protein lipidation
sphingolipid metabolic process
positive regulation of gene expression
arachidonic acid metabolic process
lipoxygenase pathway
lipid oxidation
positive regulation of MAPK cascade
linoleic acid metabolic process
ceramide biosynthetic process
hepoxilin biosynthetic process
establishment of skin barrier
positive regulation of mucus secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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