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Invitrogen
LRRC16A Polyclonal Antibody
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Product Details
PA5-56045
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human LRRC16A. Recombinant protein control fragment (Product #RP-94632).
Conjugate
Form
Liquid
Concentration
0.90 mg/mL
Amount
90 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RSDSKSSPQA GRRYGVQVMG SGLLAEMKAK QEKRAACAQK KLGNDAVSQD SSSPALSSVE RSDGGGAVPK LHPGLPENRF GLGTPEKNTK AEPKAEA
Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 77%.
Target Information
Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Capping protein regulator and myosin 1 linker protein 1; Capping protein, Arp2/3 and myosin-I linker homolog 1; Capping protein, Arp2/3 and myosin-I linker protein 1; capping protein, Arp2/3, and Myosin-I Linker homolog 1; CARMIL homolog; cytoskeleton protein; F-actin-uncapping protein LRRC16A; leucine rich repeat containing 16; leucine rich repeat containing 16A; Leucine-rich repeat-containing protein 16A; testicular tissue protein Li 107; unnamed protein product
Gene Aliases: CARMIL; CARMIL1; CARMIL1a; dJ501N12.1; dJ501N12.5; LRRC16; LRRC16A
UniProt ID: (Human) Q5VZK9
Entrez Gene ID: (Human) 55604
actin filament organization
cell migration
lamellipodium assembly
positive regulation of cell migration
positive regulation of actin filament polymerization
ruffle organization
regulation of Arp2/3 complex-mediated actin nucleation
macropinocytosis
urate metabolic process
positive regulation of stress fiber assembly
barbed-end actin filament uncapping
actin filament network formation
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of lamellipodium organization
negative regulation of barbed-end actin filament capping
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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