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Invitrogen
RGN Polyclonal Antibody
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Product Details
PA5-56057
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RGN. Recombinant protein control fragment (Product #RP-95633).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DAEGKLWVAC YNGGRVIRLD PVTGKRLQTV KLPVDKTTSC CFGGKNYSEM YVTCARDGMD PEGLLRQPEA GGIFKITGLG VKGIAPYSY
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
Target Information
The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis secretory protein Li 41; Gluconolactonase; GNL; RC; Regucalcin; Senescence marker protein 30; SMP-30; unnamed protein product
Gene Aliases: AI265316; GNL; HEL-S-41; RC; Reguc; RGN; SMP30
UniProt ID: (Human) Q15493, (Rat) Q03336, (Mouse) Q64374
Entrez Gene ID: (Human) 9104, (Rat) 25106, (Mouse) 19733
cellular calcium ion homeostasis
positive regulation of ATPase activity
regulation of calcium-mediated signaling
kidney development
liver development
negative regulation of protein phosphorylation
negative regulation of protein kinase activity
spermatogenesis
aging
positive regulation of triglyceride biosynthetic process
positive regulation of glucose metabolic process
positive regulation of phosphatase activity
L-ascorbic acid biosynthetic process
negative regulation of phosphoprotein phosphatase activity
negative regulation of GTPase activity
negative regulation of apoptotic process
positive regulation of GTPase activity
negative regulation of nitric oxide biosynthetic process
positive regulation of fatty acid biosynthetic process
negative regulation of epithelial cell proliferation
negative regulation of cyclic-nucleotide phosphodiesterase activity
liver regeneration
negative regulation of sperm motility
positive regulation of superoxide dismutase activity
positive regulation of calcium-transporting ATPase activity
negative regulation of RNA biosynthetic process
negative regulation of bone development
positive regulation of proteolysis involved in cellular protein catabolic process
negative regulation of calcium-dependent ATPase activity
negative regulation of DNA catabolic process
positive regulation of dUTP diphosphatase activity
negative regulation of leucine-tRNA ligase activity
negative regulation of DNA biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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