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Invitrogen
Kir2.1 (KCNJ2) Polyclonal Antibody
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Product Details
PA5-56059
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KCNJ2. Recombinant protein control fragment (Product #RP-90945).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YEVPNTPLCS ARDLAEKKYI LSNANSFCYE NEVALTSKEE DDSENGVPES
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 98%.
Target Information
The KIR2 subunit family includes 2. 1, 2. 2, 2. 3 and 2. 4. Unlike G protein-coupled KIR3 subunits, KIR2. 1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity. KIR2. 1 is expressed in the superior and inferior collicula and the pontine region of the brain, where it moderates synaptic transmission, like many other potassium channels. In the placenta, KIR2. 1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, KIR2. 1 colocalizes with KIR5. 1 in the proximal tubule. KIR2. 1, 2. 2 and 2. 3 associate with the membrane-associated guanylate kinase synapseassociated protein 97 in the cerebellum and heart. Phosphorylation of KIR2. 2 by protein kinase A inhibits the associates with SAP97.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cardiac inward rectifier potassium channel; HEos-IRK; HHIRK 1; HIRK 1; hIRK1; Inward rectifier K; Inward rectifier K(+) channel Kir2.1; inward rectifier K+ channel KIR2.1; Inward rectifier potassium channel 2; IRK 1; IRK-1; IRK2; LQT 7; Potassium channel, inwardly rectifying subfamily J member 2; potassium channel, inwardly rectifying subfamily J, member 2; potassium voltage-gated channel subfamily J member 2; SQT 3; unnamed protein product
Gene Aliases: ATFB9; HHBIRK1; HHIRK1; IRK1; KCNJ2; KIR2.1; LQT7; SQT3
UniProt ID: (Human) P63252
Entrez Gene ID: (Human) 3759
ion transport
potassium ion transport
regulation of skeletal muscle contraction via regulation of action potential
magnesium ion transport
cellular potassium ion homeostasis
ion transmembrane transport
regulation of ion transmembrane transport
protein homotetramerization
relaxation of cardiac muscle
regulation of resting membrane potential
regulation of membrane repolarization
cellular response to mechanical stimulus
potassium ion transmembrane transport
cardiac muscle cell action potential
cardiac muscle cell action potential involved in contraction
regulation of cardiac muscle cell contraction
membrane repolarization during action potential
membrane depolarization during cardiac muscle cell action potential
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
relaxation of skeletal muscle
positive regulation of potassium ion transmembrane transport
potassium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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