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Invitrogen
BCDIN3D Polyclonal Antibody
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Product Details
PA5-58979
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BCDIN3D. Recombinant protein control fragment (Product #RP-97875).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EPQPWKCYRA AARRLRKLGL HDFDHFHSLA IRGDMPNQIV QILTQDHGME LICCFGNTSW DRSLLLFRAK QTIETHPIPE SLIEKGKEKN RLSFQKQ
Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 73%.
Target Information
O-methyltransferase that specifically monomethylates 5'- monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre- miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BCDIN3 domain containing RNA methyltransfease; BCDIN3 domain-containing protein; probable methyltransferase BCDIN3D; RNA 5'-monophosphate methyltransferase
Gene Aliases: BCDIN3D
UniProt ID: (Human) Q7Z5W3
Entrez Gene ID: (Human) 144233
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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