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Invitrogen
GASP2 Polyclonal Antibody
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Product Details
PA5-60654
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GASP2. Recombinant protein control fragment (Product #RP-102961).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: STCERECSRD QDCAAAEKCC INVCGLHSCV AARFPGSPAA PTTAASCEGF VCPQQGSDCD I
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 82%.
Target Information
The GASP2 gene encodes for a protein known as G protein-coupled receptor-associated sorting protein 2. GASP2 is involved in the regulation of G protein-coupled receptors (GPCRs), which are crucial for transmitting signals from the external environment to the inside of a cell. This protein plays a key role in the intracellular trafficking and sorting of GPCRs, affecting their recycling and degradation pathways, which are critical for receptor resensitization and downregulation. GASP2 assists in marking GPCRs for degradation post endocytosis, thereby influencing receptor availability on the cell surface and modulating cellular responsiveness to ligands. Dysregulation of GASP2 expression or function can impact GPCR signaling pathways, potentially affecting various physiological processes and contributing to disease states where GPCR signaling is altered, such as in certain neurological disorders and cancers. The role of GASP2 in GPCR regulation makes it a point of interest for therapeutic targeting to modulate GPCR-related signaling pathways for clinical benefits in diverse diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GASP-2; Growth and differentiation factor-associated serum protein 2; hGASP-2; WAP four-disulfide core domain 20A; WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein; WAP, FS, Ig, KU, and NTR-containing protein; WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
Gene Aliases: C16orf12; GASP2; PSEC0040; RJD2; WFDC20A; WFIKKN; WFIKKN1
UniProt ID: (Human) Q96NZ8
Entrez Gene ID: (Human) 117166
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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