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Invitrogen
HM13 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-60919
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HM13. Recombinant protein control fragment (Product #RP-91119).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PASFPNRQYQ LLFTQGSGEN KEEIINYEFD TKDLVCLGLS SIVGVWYLLR KHWIANNLFG LAFSLNGVEL LHLNNVSTGC
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
Target Information
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139- dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hIMP1; histocompatibility (minor) 13 isoform HM13_1; histocompatibility (minor) 13 isoform HM13_2; HM13 intronic transcript 1; hPSRP; IMPAS; intramembrane protease 1; minor histocompatibility antigen 13; minor histocompatibility antigen H13; presenilin-like protein 3; signal peptide peptidase beta; signal peptide peptidase like 1; SPP beta; unnamed protein product
Gene Aliases: H13; HM13-IT1; IMP1; IMPAS; IMPAS-1; MSTP086; PSENL3; PSL3; SPP; SPPL1
UniProt ID: (Human) Q8TCT9
Entrez Gene ID: (Human) 81502
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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