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Invitrogen
EID2 Polyclonal Antibody
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Product Details
PA5-61012
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human EID2. Recombinant protein control fragment (Product #RP-99182).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AREAAFDAEY QRNPHRVDLD ILTFTIALTA SEVINPLIEE LGCDKFINRE
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.
Target Information
EID2 interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. It may act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CREBBP/EP300 inhibitor 2; CREBBP/EP300 inhibitory protein 2; E1A like inhibitor of differentiation 2; EID-1-like inhibitor of differentiation 2; EID-2; EP300-interacting inhibitor of differentiation 2; unnamed protein product
Gene Aliases: CRI2; EID-2; EID2
UniProt ID: (Human) Q8N6I1
Entrez Gene ID: (Human) 163126
negative regulation of transcription from RNA polymerase II promoter
transforming growth factor beta receptor complex assembly
muscle organ development
cell differentiation
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of cell proliferation
negative regulation of transcription, DNA-templated
negative regulation of SMAD protein import into nucleus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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