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Invitrogen
NKCC1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-66620
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human NKCC1. Recombinant protein control fragment (Product #RP-107279).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QCLVMTGAPNS RPALLHLVHD FTKNVGLMIC GHVHMGPRRQ AMKEMSIDQA KYQRWLI
Highest antigen sequence identity to the following orthologs - mouse 97%, rat 98%.
Target Information
NKCC1 mediates sodium and chloride transport and reabsorption. NKCC1 is a membrane protein and is important in maintaining proper ionic balance and cell volume. NKCC1 is an electrically silent transporter system that mediates sodium and chloride reabsorption. Further, NKCC1 plays a vital role in the regulation of ionic balance and cell volume and is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for NKCC1. Diseases associated with SLC12A2 include Basosquamous Carcinoma and Metatypical Basal Cell Carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: basolateral Na-K-Cl symporter; bumetanide-sensitive cotransporter type 2; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; cation-chloride cotransporter; membrane electrolyte transporter; Na-K-2Cl cotransporter 1; protein phosphatase 1, regulatory subunit 141; solute carrier family 12 (sodium/potassium/chloride transporter), member 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2
Gene Aliases: BSC; BSC-2; BSC2; CCC1; hNKCC1; KILQS; NKCC1; PPP1R141
UniProt ID: (Human) P55011
Entrez Gene ID: (Human) 6558
protein binding
sodium:potassium:chloride symporter activity
ammonium transmembrane transporter activity
potassium ion transmembrane transporter activity
cation:chloride symporter activity
protein kinase binding
transmembrane transporter activity
metal ion transmembrane transporter activity
chaperone binding
Hsp90 protein binding
protein serine/threonine kinase binding
ion transport
potassium ion transport
sodium ion transport
chloride transport
cellular sodium ion homeostasis
cell volume homeostasis
hyperosmotic response
gamma-aminobutyric acid signaling pathway
T cell chemotaxis
cellular potassium ion homeostasis
transepithelial chloride transport
cellular chloride ion homeostasis
maintenance of blood-brain barrier
sodium ion transmembrane transport
cellular response to potassium ion
positive regulation of cell volume
transmembrane transport
negative regulation of vascular wound healing
transepithelial ammonium transport
potassium ion transmembrane transport
ammonium transmembrane transport
inorganic anion import across plasma membrane
inorganic cation import across plasma membrane
sodium ion import across plasma membrane
regulation of spontaneous synaptic transmission
transport across blood-brain barrier
chloride transmembrane transport
positive regulation of aspartate secretion
regulation of matrix metallopeptidase secretion
potassium ion import across plasma membrane
cellular response to chemokine
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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