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Invitrogen
KIAA0196 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-67132
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human KIAA0196. Recombinant protein control fragment (Product #RP-107779).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HRGLIFNPRAK PSELMPKLKE LGATMDGFHR SFEYIQDYVN IYGLKIWQEE VSRIINYNVE QECNNFLRTK IQDWQSMYQS THIPIPKFTP VD
Highest antigen sequence identity to the following orthologs - mouse 98%, rat 98%.
Target Information
This gene encodes a 134 kDa protein named strumpellin that is predicted to have multiple transmembrane domains and a spectrin-repeat-containing domain. This ubiquitously expressed gene has its highest expression in skeletal muscle. The protein is named for Strumpell disease; a form of hereditary spastic paraplegia (HSP). Spastic paraplegias are a diverse group of disorders in which the autosomal dominant forms are characterized by progressive, lower extremity spasticity caused by axonal degeneration in the terminal portions of the longest descending and ascending corticospinal tracts. More than 30 loci (SPG1-33) have been implicated in hereditary spastic paraplegia diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KIAA0196; strumpellin; unnamed protein product; WASH complex subunit strumpellin
Gene Aliases: KIAA0196; RTSC; RTSC1; SPG8
UniProt ID: (Human) Q12768
Entrez Gene ID: (Human) 9897
oocyte maturation
endosome organization
positive regulation of neuron projection development
endosomal transport
actin filament polymerization
regulation of Arp2/3 complex-mediated actin nucleation
polar body extrusion after meiotic divisions
regulation of actin nucleation
spindle assembly involved in meiosis
endosome fission
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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