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Invitrogen
HEY2 Polyclonal Antibody
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Product Details
PA5-67365
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human HEY2. Recombinant protein control fragment (Product #RP-108022).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PCEETTSESDM DETIDVGSEN NYSGQSTSSV IRLNSPTTTS QIMARKK
Highest antigen sequence identity to the following orthologs - mouse 88%, rat 90%.
Target Information
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHb32; cardiovascular basic helix-loop-helix factor 1; Cardiovascular helix-loop-helix factor 1; CHF1; Class B basic helix-loop-helix protein 32; h hHRT2; Hairy and enhancer of split-related protein 2; Hairy-related transcription factor 2; hairy/enhancer-of-split related with YRPW motif 2; Hairy/enhancer-of-split related with YRPW motif protein 2; hCHF1; HES-related repressor protein 1; HES-related repressor protein 2; HESR-2; hGRL; basic helix-loop-helix transcription factor; hHRT2; HRT-2; HRT2; Protein gridlock homolog; transcription factor; unnamed protein product
Gene Aliases: BHLHB32; CHF1; GRIDLOCK; GRL; HERP; HERP1; HESR2; HEY2; HRT2
UniProt ID: (Human) Q9UBP5
Entrez Gene ID: (Human) 23493
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
histone deacetylase binding
sequence-specific DNA binding
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
blood vessel development
vasculogenesis
muscular septum morphogenesis
outflow tract morphogenesis
cardiac conduction system development
atrioventricular valve development
aortic valve morphogenesis
pulmonary valve morphogenesis
tricuspid valve morphogenesis
tricuspid valve formation
epithelial to mesenchymal transition involved in endocardial cushion formation
endocardial cushion to mesenchymal transition involved in heart valve formation
cardiac ventricle morphogenesis
cardiac left ventricle morphogenesis
cardiac right ventricle morphogenesis
ventricular trabecula myocardium morphogenesis
cardiac muscle hypertrophy
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
pattern specification process
heart development
anatomical structure morphogenesis
anterior/posterior axis specification
anterior/posterior pattern specification
positive regulation of heart rate
regulation of gene expression
negative regulation of gene expression
cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
mesenchymal cell development
cardiac muscle hypertrophy in response to stress
ascending aorta morphogenesis
dorsal aorta morphogenesis
umbilical cord morphogenesis
cell fate commitment
regulation of auditory receptor cell differentiation
negative regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of neurogenesis
smooth muscle cell differentiation
negative regulation of smooth muscle cell differentiation
ventricular cardiac muscle cell development
cardiac muscle cell proliferation
positive regulation of cardiac muscle cell proliferation
cardiac epithelial to mesenchymal transition
heart trabecula formation
cardiac septum morphogenesis
ventricular septum morphogenesis
atrial septum morphogenesis
negative regulation of transcription initiation from RNA polymerase II promoter
labyrinthine layer blood vessel development
blood vessel endothelial cell differentiation
artery development
arterial endothelial cell differentiation
cardiac vascular smooth muscle cell development
coronary vasculature morphogenesis
pulmonary artery morphogenesis
protein-DNA complex assembly
negative regulation of biomineral tissue development
circulatory system development
cochlea development
vascular smooth muscle cell development
negative regulation of cardiac vascular smooth muscle cell differentiation
regulation of vasculogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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