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Invitrogen
Cyclin T1 Polyclonal Antibody
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Product Details
PA5-82177
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CCNT1. Recombinant protein control fragment (Product #RP-102511).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KTSEQTILNM ISQSSSDTTI AGLMSMSTST TSAVPSLPVS EESSSNLTSV EMLPGKRWLS SQPSFKLEPT QGHRTSENLA LTGVDHSLPQ DGSNAFISQK QNSKSVPSAK VSLKEYRAKH AEELAAQKRQ LEN
Highest antigen sequence indentity to the following orthologs: Mouse - 86%, Rat - 86%.
Target Information
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDK9-associated C-type protein; cyclin C-related protein; cyclin T1b; cyclin-T; Cyclin-T1; CycT1; human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1; MLLT10/CCNT1 fusion; unnamed protein product
Gene Aliases: 2810478G24Rik; AI115585; CCNT; CCNT1; CYCT1; HIVE1
UniProt ID: (Human) O60563, (Mouse) Q9QWV9
Entrez Gene ID: (Human) 904, (Rat) 315291, (Mouse) 12455
transcription regulatory region sequence-specific DNA binding
DNA binding
chromatin binding
protein binding
cyclin-dependent protein serine/threonine kinase regulator activity
snRNA binding
protein kinase binding
cyclin-dependent protein serine/threonine kinase activator activity
RNA polymerase binding
7SK snRNA binding
DNA-binding transcription factor binding
molecular condensate scaffold activity
molecular_function
transcription regulatory region DNA binding
kinase activator
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
response to xenobiotic stimulus
positive regulation of DNA-templated transcription, elongation
positive regulation of transcription elongation from RNA polymerase II promoter
positive regulation by host of viral transcription
positive regulation of transcription from RNA polymerase II promoter
cell division
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
biological_process
response to drug
negative regulation of mRNA polyadenylation
cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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