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Invitrogen

IRF3 Polyclonal Antibody

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IRF3 Polyclonal Antibody

Product Details

PA5-82178

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human IRF3. Recombinant protein control fragment (Product #RP-102261).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2789339

Product Specific Information

Immunogen sequence: VNKSRTRFRI PWKHGLRQDA QQEDFGIFQA WAEATGAYVP GRDKPDLPTW KRNFRSALNR KEGLRLAEDR SKDPHDPHKI YEFVNSGVGD FSQPDTSPDT NGGGSTSDTQ EDILDELLGN MVLAPLPDPG PPSLAVAPEP CPQ

Highest antigen sequence indentity to the following orthologs: Mouse - 64%, Rat - 71%.

Target Information

IFR3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IFR3 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. It acts as a more potent activator of the IFN-beta gene than the IFN-alpha gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. IFR3 is found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling. It is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Mutations in the gene can result in encephalopathy, acute, infection-induced, herpes-specific 7.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Interferon regulatory factor 3; IRF-3; IRF-3a; IRF-3b; IRF-3c; IRF-3d; IRF-3e; IRF-3f; IRF3 (phospho S386); IRF3 (pS386); IRF3 (pSer386); IRF3 phospho; IRF3 phospho S386; IRF3 phospho Ser386; phospho IRF3; unnamed protein product

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Gene Aliases: IIAE7; IRF3

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UniProt ID: (Human) Q14653

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Entrez Gene ID: (Human) 3661

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein domain specific binding identical protein binding protein homodimerization activity sequence-specific DNA binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter positive regulation of cytokine production immune system process cytoplasmic pattern recognition receptor signaling pathway regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process cellular response to DNA damage stimulus cell surface receptor signaling pathway mRNA transcription response to bacterium regulation of gene expression programmed cell death signal transduction involved in regulation of gene expression lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production response to lipopolysaccharide positive regulation of interferon-alpha production positive regulation of interferon-beta production toll-like receptor 4 signaling pathway TRIF-dependent toll-like receptor signaling pathway MDA-5 signaling pathway regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA innate immune response positive regulation of innate immune response positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of inflammatory response defense response to virus type I interferon signaling pathway positive regulation of type I interferon-mediated signaling pathway cellular response to lipopolysaccharide cellular response to exogenous dsRNA macrophage apoptotic process programmed necrotic cell death cellular response to virus antiviral innate immune response cGAS/STING signaling pathway positive regulation of cytokine production involved in inflammatory response
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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