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Invitrogen
CD63 Polyclonal Antibody
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Product Details
PA5-82391
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CD63. Recombinant protein control fragment (Product #RP-90638).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RDKVMSEFNN NFRQQMENYP KNNHTASILD RMQADFKCCG AANYTDWEKI PSMSKNRVPD SCCINVTVGC GINFNEKAIH KEGCVEKIG
Highest antigen sequence indentity to the following orthologs: Mouse - 65%, Rat - 63%.
Target Information
CD63, also known as LAMP-3, is a glycoprotein belonging to the tetraspanin family, primarily located in late endosomes, lysosomes, and secretory vesicles across various cell types. It is expressed intracellularly in resting platelets and basophils, but upon activation, CD63 translocates to the plasma membrane, making it a widely used marker for basophil activation. Unlike basophils, mast cells can expose CD63 without activation. CD63 is expressed on activated platelets, monocytes, macrophages, and granulocytes, as well as endothelial cells, fibroblasts, and smooth muscle cells. It interacts with integrins (such as VLA-3 and VLA-6) and TIMP-1, playing roles in mediating allergic responses, phagocytosis, and cell migration. Additionally, CD63 is involved in the regulation of H/K-ATPase trafficking and ROMK1 channels, and serves as a T-cell costimulation molecule. CD63 expression can be used to predict prognosis in early-stage carcinomas and is identical to the melanoma-associated antigen ME491 and the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome, highlighting its significance in both immune responses and disease processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AD1 antigen; CD 63; CD63; CD63 antigen; CD63 antigen (melanoma 1 antigen); Granulophysin; LAMP-3; LAMP-3; CD63; ME491; Limp1; Lysosomal-associated membrane protein 3; Lysosome integral membrane protein 1; Melanoma-associated antigen ME491; melanoma-associated antigen MLA1; Ocular melanoma-associated antigen; OMA81H; Tetraspanin-30; Tspan-30; unnamed protein product
Gene Aliases: AD1; CD63; HOP-26; ME491; MLA1; OMA81H; Pltgp40; TSPAN30
UniProt ID: (Human) P08962
Entrez Gene ID: (Human) 967
positive regulation of receptor internalization
cell-matrix adhesion
negative regulation of epithelial cell migration
protein transport
cell migration
cell differentiation
epithelial cell differentiation
endosome to melanosome transport
pigmentation
positive regulation of cell adhesion
positive regulation of endocytosis
pigment granule maturation
pigment cell differentiation
regulation of vascular endothelial growth factor signaling pathway
regulation of potassium ion transmembrane transport
positive regulation of integrin-mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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