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Invitrogen
CTH Polyclonal Antibody
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FIGURE: 1 / 8
CTH Antibody (PA5-82768) in IHC (P)
Immunohistochemistry analysis of CTH in human colon, liver, lymph node and testis. Samples were incubated with CTH polyclonal antibody (Product # PA5-82768). Shows similar protein distribution across tissues to independent CTH antibody (Product # PA5-82825) (B).
Product Details
PA5-82768
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CTH. Recombinant protein control fragment (Product #RP-93138).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KAGDQIICMD DVYGGTNRYF RQVASEFGLK ISFVDCSKIK LLEAAITPET KLVWIETPTN PTQKVIDIEG CAHIVHKHGD IILVVDNTFM SPYFQRPLAL GAD
Highest antigen sequence indentity to the following orthologs: Rat - 86%, Mouse - 87%.
Target Information
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CGL; cystathionase (cystathionine gamma-lyase); Cystathionine gamma-lyase; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; homoserine deaminase; homoserine dehydratase; MGC9471; unnamed protein product
Gene Aliases: CGL; CSE; CTH
UniProt ID: (Human) B4E1R2
Entrez Gene ID: (Human) 1491
cysteine metabolic process
lipid metabolic process
cellular amino acid biosynthetic process
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
cysteine biosynthetic process via cystathionine
cysteine biosynthetic process
transsulfuration
endoplasmic reticulum unfolded protein response
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
protein sulfhydration
protein homotetramerization
hydrogen sulfide biosynthetic process
positive regulation of aortic smooth muscle cell differentiation
cellular response to leukemia inhibitory factor
negative regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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