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Invitrogen
GSK3 alpha Polyclonal Antibody
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Product Details
PA5-83011
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GSK3A. Recombinant protein control fragment (Product #RP-95197).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SFFDELRCLG TQLPNNRPLP PLFNFSAGEL SIQPSLNAIL IPPHLRSPAG TTTLTPSSQA LTETPTSSDW QSTDATPTLT NSS
Highest antigen sequence indentity to the following orthologs: Mouse - 75%, Rat - 87%.
Target Information
Glycogen synthase kinase 3 alpha (GSK3A) is a multifunctional protein serine/threonine kinase implicated in the control of several regulatory proteins and transcription factors. (GSK3A Alias: DKFZp686D0638). Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686D0638; Glycogen synthase kinase-3 alpha; GSK-3 alpha; gsk-3-alpha; OTTHUMP00000198368; Serine/threonine-protein kinase GSK3A
Gene Aliases: GSK3A
UniProt ID: (Human) P49840
Entrez Gene ID: (Human) 2931
regulation of systemic arterial blood pressure
cardiac left ventricle morphogenesis
glycogen metabolic process
nervous system development
insulin receptor signaling pathway
negative regulation of signal transduction
positive regulation of autophagy
positive regulation of gene expression
negative regulation of UDP-glucose catabolic process
regulation of neuron projection development
Wnt signaling pathway
cell migration
viral protein processing
cell differentiation
positive regulation of protein ubiquitination
lipopolysaccharide-mediated signaling pathway
negative regulation of TOR signaling
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to insulin stimulus
cellular response to interleukin-3
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of neuron apoptotic process
negative regulation of glycogen biosynthetic process
positive regulation of protein catabolic process
positive regulation of heart contraction
positive regulation of transcription from RNA polymerase II promoter
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
excitatory postsynaptic potential
negative regulation of cell growth involved in cardiac muscle cell development
regulation of microtubule cytoskeleton organization
cellular response to lithium ion
cellular response to glucocorticoid stimulus
positive regulation of adrenergic receptor signaling pathway
negative regulation of canonical Wnt signaling pathway
extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
autosome genomic imprinting
beta-arrestin-dependent dopamine receptor signaling pathway
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of mitophagy
cellular response to oxygen-containing compound
positive regulation of beta-amyloid formation
positive regulation of protein targeting to mitochondrion
positive regulation of establishment of protein localization
negative regulation of type B pancreatic cell development
negative regulation of glycogen (starch) synthase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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