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Invitrogen
PRDX5 Polyclonal Antibody
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Product Details
PA5-83396
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PRDX5. Recombinant protein control fragment (Product #RP-102791).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MGLAGVCALR RSAGYILVGG AGGQSAAAAA RRCSEGEWAS GGVRSFSRAA AAMAPIKVGD AIPAVEVFEG EPGN
Highest antigen sequence indentity to the following orthologs: Rat - 51%, Mouse - 43%.
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alu co-repressor 1; Alu corepressor 1; Antioxidant enzyme B166; AOEB166; epididymis secretory protein Li 55; hAOEB166; alkyl hydroperoxide reductase; thioredoxin peroxidase; Liver tissue 2D-page spot 71B; Peroxiredoxin V; Peroxiredoxin-5, mitochondrial; Peroxisomal antioxidant enzyme; PLP; PMP20; PRDX5; Prx-V; Prx5; Thioredoxin peroxidase PMP20; thioredoxin reductase; Thioredoxin-dependent peroxiredoxin 5; TPx type VI
Gene Aliases: ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20; PRDX5; PRDX6; prx-V; PRXV; SBBI10
UniProt ID: (Human) P30044
Entrez Gene ID: (Human) 25824
RNA polymerase III regulatory region DNA binding
peroxidase activity
receptor binding
protein binding
thioredoxin peroxidase activity
antioxidant activity
oxidoreductase activity
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
peroxynitrite reductase activity
thioredoxin-dependent peroxiredoxin activity
inflammatory response
response to oxidative stress
negative regulation of transcription from RNA polymerase III promoter
positive regulation of collagen biosynthetic process
cellular response to oxidative stress
cellular response to reactive oxygen species
hydrogen peroxide catabolic process
negative regulation of apoptotic process
cell redox homeostasis
negative regulation of oxidoreductase activity
regulation of apoptosis involved in tissue homeostasis
cellular oxidant detoxification
reactive nitrogen species metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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