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Invitrogen
INCENP Polyclonal Antibody
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Product Details
PA5-84062
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human INCENP. Recombinant protein control fragment (Product #RP-108204).
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Amount
80 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KLMEFLCNMD NKDLVWLEEI QEEAERMFTR EFSKEPELMP KTPSQKNRRK KRRISYVQDE NRDPIRRRLS RRKSRSSQLS SRRLRSKDSV EKLATVVGE
Highest antigen sequence indentity to the following orthologs: Rat - 66%, Mouse - 69%.
Target Information
Chromosomal passenger proteins are members of a group of proteins that move from centromeres to the spindle midzone during mitosis. INCENP (Inner Centromere Protein) is a chromosomal passenger protein with an essential role in mitosis and meiosis. It is a complex highly basic multidomain protein that is dynamically translocated from metaphase chromosomes to the spindle midzone during or just prior to anaphase. Some INCENP transfers to the equatorial cortex before formation of the cleavage furrow. Ultimately, it is discarded in the midbody at the completion of cytokinesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: binds and activates aurora-B and -C in vivo and in vitro; chromosomal passenger; chromosomal passenger protein; Inner centromere protein; inner centromere protein antigens 135/155kDa; inner centromere protein INCENP; unnamed protein product
Gene Aliases: INCENP
UniProt ID: (Human) Q9NQS7
Entrez Gene ID: (Human) 3619
mitotic cell cycle
mitotic cytokinesis
chromosome segregation
mitotic spindle midzone assembly
meiotic spindle midzone assembly
cell division
metaphase plate congression
positive regulation of mitotic cell cycle spindle assembly checkpoint
mitotic spindle assembly
positive regulation of mitotic sister chromatid separation
positive regulation of attachment of mitotic spindle microtubules to kinetochore
positive regulation of mitotic cytokinesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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