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Invitrogen
CDX1 Polyclonal Antibody
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Product Details
PA5-84244
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CDX1. Recombinant protein control fragment (Product #RP-100050).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VGYVLDKDSP VYPGPARPAS LGLGPQAY
Highest antigen sequence indentity to the following orthologs: Rat - 57%, Mouse - 89%.
Target Information
CDX1, or caudal type homeobox 1, is a gene encoding a homeodomain transcription factor that plays a significant role in the development and differentiation of intestinal epithelial cells. CDX1 is expressed in the intestinal crypts, where it is integral to the Wnt/B-catenin signaling pathway, crucial for cell proliferation. Interestingly, while CDX1 expression is initially active, its expression is often silenced as colon cancer progresses in humans, suggesting a complex role in tumor biology. The CDX1 protein functions as a transcriptional regulator that influences proliferation and differentiation, expressing early during intestinal development. In mice, it is involved in the development of the posterior embryo and is associated with abnormal differentiation in metaplastic and neoplastic tissues, providing insight into intestinal-type gastric adenocarcinoma progression. CDX1 is related to other vertebrate Cdx genes such as Cdx2 and Cdx4, which are homologues of the Drosophila caudal gene and are also implicated in embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: caudal type homeo box transcription factor 1; caudal type homeobox transcription factor 1; Caudal-type homeobox protein 1; caudal-type homeobox protein CDX1; Homeobox protein CDX-1
Gene Aliases: CDX1
UniProt ID: (Human) P47902
Entrez Gene ID: (Human) 1044
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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