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Invitrogen
D2HGDH Polyclonal Antibody
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Product Details
PA5-100063
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human D2HGDH(Accession Q8N465), corresponding to amino acid residues E409-P459.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total D2HGDH.
Target Information
This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: D-2-hydroxyglutarate dehydrogenase, mitochondrial; D2hgdh {ECO:0000250|UniProtKB:Q8N465}; FLJ42195; MGC25181; unnamed protein product
Gene Aliases: AA408776; AA408778; AI325464; D2HGD; D2HGDH; RGD1307976
UniProt ID: (Human) Q8N465, (Mouse) Q8CIM3, (Rat) P84850
Entrez Gene ID: (Human) 728294, (Mouse) 98314, (Rat) 301624
catalytic activity
zinc ion binding
oxidoreductase activity
metal ion binding
flavin adenine dinucleotide binding
(R)-2-hydroxyglutarate dehydrogenase activity
FAD binding
UDP-N-acetylmuramate dehydrogenase activity
oxidoreductase activity, acting on CH-OH group of donors
limonene-1,2-diol dehydrogenase activity
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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