Search

  • お問い合わせ一覧​
  • クイックオーダー

Invitrogen

p35 Polyclonal Antibody

View all (9) p35 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
p35 Polyclonal Antibody

Product Details

PA5-101168

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CDK5R1(Accession Q15078), corresponding to amino acid residues K13-K63.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2850611

Product Specific Information

Antibody detects endogenous levels of total CDK5R1/P35.

Target Information

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: CDK5 activator 1; cyclin-dependent kinase 5, regulatory subunit (p35) 1; neuronal CDK5 activator; p23; p35; regulatory partner for CDK5 kinase; tau protein kinase II 23 kDa subunit; tau protein kinase II 23kDa subunit; TPKII regulatory subunit; unnamed protein product

View more View less

Gene Aliases: CDK5P35; CDK5R; D11Bwg0379e; NCK5A; p23; p25; p35; p35nck5a

View more View less

UniProt ID: (Human) Q15078, (Mouse) P61809, (Rat) P61810

View more View less

Entrez Gene ID: (Human) 8851, (Mouse) 12569, (Rat) 116671

View more View less

Function(s)
protease binding actin binding protein kinase activity calcium ion binding protein binding kinase activity protein kinase binding protein kinase activator activity ionotropic glutamate receptor binding alpha-tubulin binding protein serine/threonine kinase activator activity cadherin binding beta-tubulin binding actin filament binding cyclin-dependent protein serine/threonine kinase activator activity cytoskeletal protein binding ephrin receptor binding
Process(es)
neuron migration neuron cell-cell adhesion G-protein coupled acetylcholine receptor signaling pathway axon guidance axonal fasciculation brain development embryo development ending in birth or egg hatching peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cerebellum development superior olivary nucleus maturation hippocampus development cerebral cortex radially oriented cell migration layer formation in cerebral cortex neuron differentiation neuron projection development regulation of actin cytoskeleton organization ionotropic glutamate receptor signaling pathway serine phosphorylation of STAT protein positive regulation of neuron apoptotic process positive regulation of MHC class II biosynthetic process positive regulation of protein kinase activity negative regulation of transcription, DNA-templated ephrin receptor signaling pathway regulation of dendritic spine morphogenesis G1 to G0 transition involved in cell differentiation regulation of microtubule cytoskeleton organization positive regulation of protein targeting to membrane regulation of synaptic vesicle cycle positive regulation of tumor necrosis factor-mediated signaling pathway regulation of cyclin-dependent protein serine/threonine kinase activity microtubule cytoskeleton organization regulation of macroautophagy positive regulation of microtubule polymerization regulation of neuron differentiation axon extension
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support