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Invitrogen
HAMP Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-102436
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human HAMP(Accession P81172), corresponding to amino acid residues A2-M52.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total HAMP.
Target Information
HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antimicrobial peptide; antimicrobial peptide precursor; hepcidin antimicrobial peptide 1; hepcidin preproprotein; liver-expressed antimicrobial peptide 1; putative liver tumor regressor
Gene Aliases: Hamp1; HEPC; Hepc1; HFE2B; LEAP1; PLTR
UniProt ID: (Human) P81172, (Rat) Q99MH3, (Mouse) Q9EQ21
Entrez Gene ID: (Human) 57817, (Rat) 84604, (Mouse) 84506
negative regulation of transcription from RNA polymerase II promoter
positive regulation of receptor internalization
cellular iron ion homeostasis
immune response
signal transduction
response to iron ion
killing of cells of other organism
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of iron ion transmembrane transport
defense response to bacterium
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
defense response to fungus
cation homeostasis
multicellular organismal iron ion homeostasis
antimicrobial humoral immune response mediated by antimicrobial peptide
inorganic ion homeostasis
positive regulation of protein polyubiquitination
negative regulation of iron export across plasma membrane
negative regulation of intestinal absorption
positive regulation of receptor catabolic process
myeloid cell homeostasis
acute-phase response
JAK-STAT cascade
response to zinc ion
response to vitamin A
response to erythropoietin
positive regulation of macrophage activation
response to ethanol
positive regulation of protein catabolic process
negative regulation of bone resorption
positive regulation of transcription from RNA polymerase II promoter
negative regulation of inflammatory response
positive regulation of cell growth involved in cardiac muscle cell development
cellular response to lipopolysaccharide
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to X-ray
liver regeneration
cellular response to bile acid
response to iron ion starvation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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