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Invitrogen
NEK2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-102746
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NEK2(Accession P51955), corresponding to amino acid residues N146-K196.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total NEK2.
Target Information
NEK2 is involved in cell cycle regulation and is essential for faithful chromosome segregation. NEK2 is a gene that encodes for a serine/threonine-protein kinase. This protein plays a crucial role in the regulation of mitosis and is primarily located in the centrosome. During the G1 phase, the protein is undetectable, but its levels progressively increase throughout the S phase, reaching their peak in late G2 phase. The gene has several alternatively spliced transcript variants that encode different isoforms with distinct C-termini. NEK2 is associated with several diseases, including Retinitis Pigmentosa 67 and Retinitis Pigmentosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NEK 2; NEK 2A; Nek2 kinase; never in mitosis A-related kinase 2; NIMA (never in mitosis gene a)-related expressed kinase 2; NIMA (never in mitosis gene a)-related kinase 2; NIMA - related expressed kinase 2; nimA-like protein kinase 1; NIMA-related expressed kinase 2; NIMA-related kinase 2; nimA-related protein kinase 2; NLK 1; protein kinase; NIMA NEK2A-t; protein phosphatase 1, regulatory subunit 111; unnamed protein product
Gene Aliases: HsPK21; NEK2A; NLK1; PPP1R111; RP67
UniProt ID: (Human) P51955, (Mouse) O35942
Entrez Gene ID: (Human) 4751, (Mouse) 18005, (Rat) 114482
mitotic sister chromatid segregation
G2/M transition of mitotic cell cycle
mitotic cell cycle
blastocyst development
protein phosphorylation
chromosome segregation
centrosome cycle
positive regulation of telomere maintenance
regulation of mitotic centrosome separation
spindle assembly
centrosome separation
regulation of attachment of spindle microtubules to kinetochore
mitotic spindle assembly
negative regulation of centriole-centriole cohesion
regulation of mitotic nuclear division
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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