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Invitrogen
Phospho-GABRB1 (Ser434) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-GABRB1 (Ser434) Antibody (PA5-104827) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-GABRB1 (Ser434) in human brain tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-GABRB1 (Ser434) polyclonal antibody (Product # PA5-104827) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-104827
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GABRB1(Accession P18505), corresponding to amino acid residues around phosphorylated Ser434.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of GABA A Receptor beta 1 only when phosphorylated at Serine 434.
Target Information
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GABA(A) receptor; GABA(A) receptor subunit beta-1; GABA(A)R beta-1; GABA-RB; GABAAR subunit beta-1; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, beta 1; gamma-aminobutyric acid (GABA) A receptor, subunit beta 1; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1; Gamma-aminobutyric acid receptor beta 1; gamma-aminobutyric acid type A receptor beta 1 subunit; gamma-aminobutyric acid type A receptor beta1 subunit; GBRB1; unnamed protein product
Gene Aliases: B230208N19Rik; DEE45; EIEE45; Gabrb-1; GARB1
UniProt ID: (Human) P18505, (Rat) P15431, (Mouse) P50571
Entrez Gene ID: (Human) 2560, (Rat) 25450, (Mouse) 14400
transmembrane signaling receptor activity
GABA-A receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
anion channel activity
ligand-gated ion channel activity
GABA-gated chloride ion channel activity
neurotransmitter receptor activity
GABA receptor binding
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
G protein-coupled neurotransmitter receptor activity
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
ion transport
chloride transport
signal transduction
G-protein coupled receptor signaling pathway
gamma-aminobutyric acid signaling pathway
response to toxic substance
central nervous system neuron development
response to progesterone
ion transmembrane transport
regulation of membrane potential
ovulation cycle
synaptic transmission, GABAergic
regulation of postsynaptic membrane potential
cellular response to histamine
regulation of presynaptic membrane potential
chloride transmembrane transport
negative regulation of synaptic transmission, GABAergic
extrasynaptic signaling via GABA
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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