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Invitrogen

Phospho-Bcl-xL (Thr47) Polyclonal Antibody

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Phospho-Bcl-xL (Thr47) Polyclonal Antibody

Product Details

PA5-104974

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human BCL2L1(Accession Q07817), corresponding to amino acid residues around phosphorylated Thr47.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816447

Product Specific Information

Antibody detects endogenous levels of BCL-XL only when phosphorylated at Threonine 47.

Target Information

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: anti-apoptosis regulatory protein; apoptosis inducer; apoptosis inhibitor; apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; bcl-x; Bcl-xBeta; bcl-xL; bcl-xS; bcl2-L-1; Bcl2-like protein 1; Bcl-xS; alternative splice variant of Bcl2l1; BCLX; BCLXL; BCLXS; DKFZp781P2092; OTTHUMP00000030550; OTTHUMP00000030552; OTTHUMP00000030555; OTTHUMP00000030556; OTTHUMP00000030557; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3; unnamed protein product

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Gene Aliases: Bcl(X)L; Bcl-X; Bcl-XL; BCL-XL/S; bcl2-L-1; BCL2L; BCLX; PPP1R52

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UniProt ID: (Human) Q07817, (Mouse) Q64373, (Rat) P53563

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Entrez Gene ID: (Human) 598, (Mouse) 12048, (Rat) 24888

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Function(s)
protein binding channel activity protein kinase binding identical protein binding BH3 domain binding clathrin binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process macromolecular complex binding GTPase binding BH domain binding MDM2/MDM4 family protein binding
Process(es)
ovarian follicle development in utero embryonic development release of cytochrome c from mitochondria response to ischemia mitochondrion organization germ cell development spermatogenesis cell proliferation positive regulation of cell proliferation male gonad development intrinsic apoptotic signaling pathway in response to DNA damage apoptotic mitochondrial changes response to radiation fertilization response to virus regulation of cytokinesis response to cytokine synaptic vesicle recycling via endosome regulation of growth regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of neuron apoptotic process response to cycloheximide regulation of mitochondrial membrane permeability neuron apoptotic process defense response to virus response to other organism regulation of mitochondrial membrane potential transmembrane transport cellular response to amino acid stimulus cellular response to alkaloid cellular response to gamma radiation apoptotic process in bone marrow negative regulation of release of cytochrome c from mitochondria extrinsic apoptotic signaling pathway in absence of ligand hepatocyte apoptotic process negative regulation of execution phase of apoptosis regulation of synaptic vesicle endocytosis positive regulation of synaptic vesicle endocytosis regulation of long term synaptic depression negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway response to ketone negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of protein localization to plasma membrane positive regulation of synaptic vesicle exocytosis positive regulation of synaptic vesicle clustering negative regulation of anoikis positive regulation of ATP biosynthetic process negative regulation of intrinsic apoptotic signaling pathway response to hypoxia response to stress response to oxidative stress response to xenobiotic stimulus response to lead ion cerebral cortex development response to lipopolysaccharide response to endoplasmic reticulum stress response to erythropoietin cellular response to erythropoietin response to hydrogen peroxide response to peptide hormone response to electrical stimulus cellular response to cAMP cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to hypoxia cellular response to xenobiotic stimulus cellular response to dexamethasone stimulus cellular response to nitric oxide response to anesthetic cellular response to astaxanthin cellular response to prolactin negative regulation of autophagy programmed cell death regulation of intracellular signal transduction regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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