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Invitrogen

Phospho-ITGB1 (Tyr783) Polyclonal Antibody

View all (106) Integrin beta 1 (CD29) antibodies

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Phospho-ITGB1 (Tyr783) Polyclonal Antibody

Product Details

PA5-106095

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ITGB1(Accession P05556), corresponding to amino acid residues around phosphorylated Tyr783.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817494

Product Specific Information

Antibody detects endogenous levels of Integrin beta 1 only when phosphorylated at Tyr783.

Target Information

CD29, also known as ITGB1 or Integrin Subunit Beta 1, is a 110 kDa cell surface glycoprotein widely expressed by various cells, including all leukocytes. It forms non-covalently linked heterodimers with at least six different alpha integrins (CD49a-f), creating VLA-1 through VLA-6 complexes, as well as with CD51. These alpha-beta integrin heterodimers mediate a range of cellular responses, including adhesion, trafficking, proliferation, and differentiation. CD29-containing integrins bind to extracellular matrix proteins such as collagen, laminin, fibronectin, and vitronectin. Some integrins also interact with cellular receptors like VCAM-1 and MadCAM-1. CD29 plays a crucial role in immune cell trafficking from blood to tissue, particularly during leukocyte emigration and extravascular migration. It is involved in regulating tissue damage and disease symptoms related to inflammatory bowel disease. In the presence of anti-tumor drugs, decreased expression of ITGB1 correlates with multidrug resistance in tumor cells. ITGB1-dependent mechanisms enhance cytokine secretion in human airway smooth muscle in response to IL-1beta, facilitated by fibronectin and type I collagen. More than eight beta subunits with numerous splice variant isoforms have been identified in mammals, including two major forms: beta1A and beta1D. Beta1A is present in all tissues except cardiac and skeletal muscle, which express the beta1D variant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: beta OL; beta oligodendroglia; collagen alpha-1(I) chain-like; fibronectin receptor subunit beta; glycoprotein IIa; integrin beta 1; integrin beta 1 (fibronectin receptor beta); integrin beta-1 subunit (cytoplasmic domain); Integrin beta1; integrin VLA-4 beta subunit; integrin VLA-4 subunit beta; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITBG1D; unnamed protein product; very late activation protein, beta polypeptide; VLA-4 subunit beta

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Gene Aliases: 4633401G24Rik; CD29; FNRB; Gm9863; GPIIA; MDF2; MSK12; VLA-BETA; VLAB

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UniProt ID: (Human) P05556, (Rat) P49134, (Mouse) P09055

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Entrez Gene ID: (Human) 3688, (Rat) 24511, (Mouse) 16412

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Function(s)
magnesium ion binding fibronectin binding protease binding actin binding obsolete cell adhesion receptor activity integrin binding calcium ion binding protein binding coreceptor activity protein kinase binding C-X3-C chemokine binding signaling receptor activity laminin binding macromolecular complex binding cadherin binding protein heterodimerization activity cell adhesion molecule binding collagen binding involved in cell-matrix adhesion integrin binding involved in cell-matrix adhesion protein tyrosine kinase binding receptor binding collagen binding kinase binding protein domain specific binding alpha-actinin binding
Process(es)
establishment of mitotic spindle orientation angiogenesis phagocytosis cellular defense response cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules leukocyte cell-cell adhesion cell-matrix adhesion calcium-independent cell-matrix adhesion transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway myoblast fusion regulation of collagen catabolic process positive regulation of fibroblast migration response to muscle activity cell migration CD40 signaling pathway cell projection organization lamellipodium assembly B cell differentiation extracellular matrix organization positive regulation of cell migration cell-substrate adhesion receptor internalization cell adhesion mediated by integrin cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion wound healing, spreading of epidermal cells maintenance of blood-brain barrier positive regulation of apoptotic process stress fiber assembly positive regulation of GTPase activity myoblast differentiation positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of angiogenesis negative regulation of vasoconstriction mesodermal cell differentiation regulation of developmental process modulation of synaptic transmission leukocyte tethering or rolling positive regulation of protein kinase B signaling positive regulation of glutamate uptake involved in transmission of nerve impulse cellular response to low-density lipoprotein particle stimulus basement membrane organization positive regulation of wound healing cell-cell adhesion regulation of spontaneous synaptic transmission reactive gliosis positive regulation of vascular endothelial growth factor signaling pathway positive regulation of protein localization to plasma membrane regulation of synapse pruning negative regulation of anoikis G1/S transition of mitotic cell cycle in utero embryonic development cell fate specification tissue homeostasis cell migration involved in sprouting angiogenesis endocytosis regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation germ cell migration visual learning response to radiation response to xenobiotic stimulus tissue development positive regulation of cell-substrate adhesion positive regulation of neuron projection development response to activity formation of radial glial scaffolds neuron projection development negative regulation of cell projection organization response to nutrient levels protein transport within lipid bilayer response to gonadotropin negative regulation of Rho protein signal transduction regulation of cell proliferation negative regulation of apoptotic process sarcomere organization negative regulation of cell differentiation negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of cell adhesion positive regulation of endocytosis axon extension cardiac muscle tissue development dendrite morphogenesis positive regulation of peptidyl-tyrosine phosphorylation positive regulation of transport regulation of cell cycle cardiac muscle cell differentiation maternal process involved in female pregnancy bicellular tight junction assembly cellular response to mechanical stimulus cellular response to vitamin D cellular response to ionizing radiation response to transforming growth factor beta establishment of Sertoli cell barrier maintenance of postsynaptic specialization structure synaptic membrane adhesion to extracellular matrix regulation of postsynaptic neurotransmitter receptor diffusion trapping regulation of neurotransmitter uptake
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