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Invitrogen
HMGB2 Polyclonal Antibody
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FIGURE: 1 / 7
HMGB2 Antibody (PA5-118390) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of HMGB2 in SH-SY5Y cells (green) using HMGB2 polyclonal Antibody (Product # PA5-118390). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. The nuclear counter stain is DAPI (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-118390
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human HMGB2 aa 22-172.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
HMGB2 encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: high mobility group protein 2; high-mobility group (nonhistone chromosomal) protein 2; HMG 2; HMG B2; HMG-2; HMG-B2; HMGB-2; unnamed protein product
Gene Aliases: HMG-2; HMG2
UniProt ID: (Human) P26583, (Rat) P52925, (Mouse) P30681
Entrez Gene ID: (Human) 3148, (Rat) 29395, (Mouse) 97165
four-way junction DNA binding
transcription regulatory region sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
DNA binding
damaged DNA binding
double-stranded DNA binding
single-stranded DNA binding
transcription coactivator activity
RNA binding
protein binding
DNA binding, bending
protein domain specific binding
chemoattractant activity
non-sequence-specific DNA binding, bending
RAGE receptor binding
supercoiled DNA binding
DNA-binding transcription factor binding
lipid binding
negative regulation of transcription from RNA polymerase II promoter
positive regulation of endothelial cell proliferation
inflammatory response to antigenic stimulus
DNA topological change
double-strand break repair via nonhomologous end joining
nucleosome assembly
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
spermatogenesis
spermatid nucleus differentiation
nervous system development
biological_process
male gonad development
positive regulation of gene expression
negative regulation of gene expression
organ regeneration
response to lipopolysaccharide
positive regulation of interferon-beta production
positive regulation of innate immune response
positive regulation of erythrocyte differentiation
positive regulation of megakaryocyte differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to steroid hormone
regulation of neurogenesis
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive chemotaxis
positive regulation of DNA metabolic process
cell chemotaxis
cellular response to lipopolysaccharide
regulation of stem cell proliferation
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
base-excision repair
chromatin organization
granzyme-mediated apoptotic signaling pathway
DNA geometric change
V(D)J recombination
regulation of hemopoiesis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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