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Invitrogen
Contactin 2 Polyclonal Antibody
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FIGURE: 1 / 2
Contactin 2 Antibody (PA5-119748) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of of TAG1 in F9 cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 1% Blocker BSA for 15 minutes at room temperature. Cells were probed with Contactin 2 Polyclonal Antibody (Product # PA5-119748) at a dilution of 1:200 for 1 hour at room temperature, washed with PBS. Alexa F... View More
Product Details
PA5-119748
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human TAG1 aa 40-230.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: Mouse cerebellum tissue lysate, human brain tissue lysate, rat cerebellum tissue lysate, F9.
Subcellular Location: Cell membrane.
Target Information
Contactin 2 (CNTN2, transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system. Contactin 2 is a member of the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol-anchor, six immunoglobulin (Ig)-like and four Fibronectin type III (FNIII)-like domains. Contactin 2 is expressed predominantly during neural development on the cell membrane of axons in nerve fiber tracts in order to guide commissural axons without promoting their growth. Contactin 2 binds with NgCAM in the plane of the same membrane (cis-binding). The Contactin 2 heterophilic (Contactin 2/NgCAM and Contactin 2/NrCAM) binding sites are localized to the first four Ig domains. The Contactin 2 homophilic (Contactin 2/Contactin 2) binding site is localized to the FNIII domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Axonal glycoprotein TAG-1; axonin; Axonin 1; Axonin-1; axonin-1 cell adhesion molecule; Axonin1; contactin 2 (axonal); contactin 2 (transiently expressed); Contactin-2; Contactin2; DKFZp781D102; MGC157722; TAX-1; Transient axonal glycoprotein 1; transiently-expressed axonal glycoprotein; unnamed protein product
Gene Aliases: AXT; CNTN2; D130012K04Rik; EPEO5; FAME5; TAG-1; TAG-564; TAG1; TAX; TAX1
UniProt ID: (Human) Q02246, (Mouse) Q61330, (Rat) P22063
Entrez Gene ID: (Human) 6900, (Mouse) 21367, (Rat) 25356
microtubule cytoskeleton organization
neuron migration
adenosine receptor signaling pathway
response to dietary excess
reduction of food intake in response to dietary excess
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
axon guidance
axonal fasciculation
learning
adult walking behavior
positive regulation of protein processing
protein processing
cerebral cortex GABAergic interneuron migration
central nervous system neuron differentiation
central nervous system myelination
regulation of cell morphogenesis
regulation of axon diameter
neuron projection development
receptor internalization
clustering of voltage-gated potassium channels
fat cell differentiation
negative regulation of neuron differentiation
regulation of neuronal synaptic plasticity
regulation of astrocyte differentiation
synapse organization
establishment of localization in cell
positive regulation of adenosine receptor signaling pathway
dendrite self-avoidance
protein localization to juxtaparanode region of axon
establishment of protein localization to juxtaparanode region of axon
presynaptic membrane organization
cell-matrix adhesion
axonogenesis
regulation of cell morphogenesis involved in differentiation
cellular protein localization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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