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Invitrogen

MST1 (STK4) Polyclonal Antibody

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MST1 (STK4) Polyclonal Antibody

Product Details

PA5-119762

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide within human MST1 aa 1-50.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

TBS, pH 7.4, with 50% glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913334

Product Specific Information

Positive Control: HepG2 cell lysate, THP-1 cell lysate, rat kidney tissue, human spleen tissue, human placenta tissue, mouse testis tissue.

Subcellular Location: Cytoplasm, Nucleus.

Target Information

STK4 (MST1) is a serine/threonine kinase which may be involved in apoptosis. It is possible that this protein induces the chromatin condensation observed in this process. STK4 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EC 2.7.11.1; hippo homolog; kinase MST1; kinase responsive to stress 2; mammalian STE20-like protein kinase 1; mammalian sterile 20-like 1; serine/threonine-protein kinase Krs-2; Sps1/Ste20-related kinase 3; STE20-like kinase MST1; sterile 20-like kinase 1; TIIAC; unnamed protein product

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Gene Aliases: Kas-2; KRS2; MST1; YSK3

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UniProt ID: (Human) Q13043, (Mouse) Q9JI11

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Entrez Gene ID: (Human) 6789, (Mouse) 58231, (Rat) 311622

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Function(s)
magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding identical protein binding protein homodimerization activity protein serine/threonine kinase activator activity RNA polymerase II sequence-specific DNA binding transcription factor binding protein serine kinase activity nucleotide binding
Process(es)
cell morphogenesis positive regulation of protein phosphorylation protein phosphorylation protein import into nucleus apoptotic process signal transduction anatomical structure morphogenesis peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation hippo signaling positive regulation of hippo signaling intracellular signal transduction positive regulation of apoptotic process regulation of MAPK cascade protein autophosphorylation protein stabilization protein tetramerization negative regulation of canonical Wnt signaling pathway positive regulation of substrate-dependent cell migration, cell attachment to substrate patterning of blood vessels neural tube formation endocardium development central nervous system development negative regulation of cell proliferation keratinocyte differentiation positive regulation of fat cell differentiation negative regulation of organ growth primitive hemopoiesis cell differentiation involved in embryonic placenta development regulation of cell differentiation involved in embryonic placenta development hepatocyte apoptotic process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of vascular associated smooth muscle cell apoptotic process
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