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Invitrogen

BCL-XL Polyclonal Antibody

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BCL-XL Polyclonal Antibody

Product Details

PA5-120030

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human Bcl-XL (NP_0013048481)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.94 mg/mL

Amount

194 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913602

Product Specific Information

Positive test controls include: OVCAR3, Rat lung, Rat spleen. The target is usually found in the following locations: Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Mitochondrion inner membrane, Mitochondrion matrix, Mitochondrion outer membrane, Nucleus membrane, Single-pass membrane protein, centrosome, cytoskeleton, cytosol, microtubule organizing center, secretory vesicle, synaptic vesicle membrane.

Immunogen sequence: MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA DSPAVNGATG HSSSLDAREV

Target Information

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; Bcl-2-like protein 1; bcl-xL; bcl-xS; Bcl2-L-1; BCLX; BCLXL; BCLXS; DKFZp781P2092; OTTHUMP00000030550; OTTHUMP00000030552; OTTHUMP00000030555; OTTHUMP00000030556; OTTHUMP00000030557; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3; unnamed protein product

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Gene Aliases: Bcl-X; Bcl-xl; BCL-XL/S; BCL2L; BCL2L1; BCLX; Blc2l; PPP1R52

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UniProt ID: (Human) Q07817, (Rat) P53563

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Entrez Gene ID: (Human) 598, (Rat) 24888

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Function(s)
protein binding channel activity protein kinase binding identical protein binding BH3 domain binding protein homodimerization activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein heterodimerization activity BH domain binding MDM2/MDM4 family protein binding
Process(es)
ovarian follicle development response to hypoxia in utero embryonic development release of cytochrome c from mitochondria response to ischemia endocytosis apoptotic process response to oxidative stress mitotic cell cycle checkpoint germ cell development spermatogenesis cell proliferation positive regulation of cell proliferation male gonad development intrinsic apoptotic signaling pathway in response to DNA damage response to radiation fertilization response to virus response to inorganic substance response to organonitrogen compound response to lead ion response to organic cyclic compound suppression by virus of host apoptotic process response to cytokine growth response to hydrogen peroxide regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to peptide hormone negative regulation of neuron apoptotic process response to cycloheximide regulation of mitochondrial membrane permeability neuron apoptotic process response to electrical stimulus regulation of mitochondrial membrane potential cellular process regulating host cell cycle in response to virus mitochondrion morphogenesis cellular response to amino acid stimulus cellular response to alkaloid cellular response to gamma radiation apoptotic process in bone marrow negative regulation of establishment of protein localization to plasma membrane negative regulation of release of cytochrome c from mitochondria extrinsic apoptotic signaling pathway in absence of ligand hepatocyte apoptotic process negative regulation of execution phase of apoptosis negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of anoikis negative regulation of intrinsic apoptotic signaling pathway response to stress mitochondrion organization apoptotic mitochondrial changes negative regulation of autophagy regulation of cytokinesis positive regulation of mononuclear cell proliferation ectopic germ cell programmed cell death regulation of growth dendritic cell proliferation epithelial cell proliferation negative regulation of developmental process defense response to virus response to other organism transmembrane transport dendritic cell apoptotic process negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of intracellular signal transduction negative regulation of protein localization to plasma membrane negative regulation of reproductive process negative regulation of dendritic cell apoptotic process regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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