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Invitrogen
p19ARF Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-142831
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-RRGPHRNPGPGDDD.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Additional Information: This antibody is expected to recognize isoform p19ARF (NP_034007.1) only.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as cell proliferation inhibitors, their mechanisms of action are different. p19ARF works as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors. This result indicates that p19ARF is an important tumor suppressor. In addition, p19ARF helps prevent transforming signals from various onocoproteins via the p53 regulatory loop. These studies and others display the importance of p19ARF in cell cycle control and tumor suppression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternative reading frame; autophagy inducer; CDK4I; cell cycle inhibitor; cell cycle regulator; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); alternatively spliced; cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor protein; mitochondrial smARF; p16-INK4; p16-INK4a; p16ink4a; unnamed protein product
Gene Aliases:
Arf; ARF-INK4a; INK4A; INK4a-ARF; Ink4a/Arf; MTS1; p16; p16(INK4a); p16Cdkn2a; p16INK4a; p19
UniProt ID: (Rat) Q9R0Z3, (Mouse) P51480
Entrez Gene ID: (Rat) 25163, (Mouse) 12578
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
p53 binding
cyclin-dependent protein serine/threonine kinase inhibitor activity
SUMO transferase activity
protein kinase binding
NF-kappaB binding
ligase inhibitor activity
ubiquitin-protein transferase inhibitor activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
MDM2/MDM4 family protein binding
disordered domain specific binding
DNA-binding transcription factor binding
ubiquitin ligase inhibitor activity
protein binding
regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of transcription from RNA polymerase II promoter
protein polyubiquitination
mitophagy
negative regulation of cell-matrix adhesion
apoptotic process
Ras protein signal transduction
negative regulation of cell proliferation
epidermis development
rRNA transcription
response to xenobiotic stimulus
response to salt stress
regulation of gene expression
cerebellum development
neurogenesis
keratinocyte differentiation
negative regulation of cell growth
nuclear body organization
negative regulation of B cell proliferation
regulation of protein stability
protein destabilization
negative regulation of immature T cell proliferation in thymus
positive regulation of protein sumoylation
negative regulation of mammary gland epithelial cell proliferation
positive regulation of smooth muscle cell apoptotic process
protein localization to nucleus
somatic stem cell population maintenance
negative regulation of protein catabolic process
glucose homeostasis
positive regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
keratinocyte proliferation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of nucleocytoplasmic transport
regulation of protein export from nucleus
somatic stem cell division
protein stabilization
regulation of cell cycle
mitochondrial depolarization
negative regulation of protein kinase B signaling
positive regulation of apoptotic process involved in mammary gland involution
response to caloric restriction
cellular response to hydrogen peroxide
protein K63-linked ubiquitination
response to fatty acid
cellular response to glucose stimulus
cellular response to gamma radiation
negative regulation of ribosome biogenesis
cellular senescence
replicative senescence
oncogene-induced cell senescence
apoptotic signaling pathway
positive regulation of protein localization to nucleus
positive regulation of signal transduction by p53 class mediator
protein localization to nucleolus
regulation of protein localization to mitochondrion
regulation of ubiquitin protein ligase activity
negative regulation of protein localization to nucleolus
amyloid fibril formation
regulation of G1/S transition of mitotic cell cycle
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of macrophage apoptotic process
negative regulation of hepatocyte proliferation
positive regulation of gene expression
negative regulation of protein neddylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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