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Invitrogen

Phospho-NFkB p65 (Ser536) Polyclonal Antibody

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Phospho-NFkB p65 (Ser536) Polyclonal Antibody

Product Details

PA5-17782

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding pSer536 of human NF-kappaB p65
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

88 µg/mL

Amount

8.8 µg

Purification

Antigen affinity chromatography, Protein A

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10974497

Product Specific Information

It is not recommended to aliquot this antibody.



This antibody is not cross-reactive with the p50 subunit or other related proteins.

Target Information

Nuclear factor kB p65 (NF-kB p65) is encoded by the RELA gene and is present on chromosome 11 in humans. NF-kB P65 is also known as RelA (v-rel avian reticuloendotheliosis viral oncogene homolog A) and belongs to the Rel family of proteins. It is one of the two subunits of NF-kB (Nuclear factor kappa-light-chain-enhancer of activated B cells) that heterodimerizes with the other subunits p50 or p52. However, binding of TNF alpha to its cognate receptor phosphorylates IKK which in turn phosphorylates I kB allowing proteasomal degradation of I kB. It specifically plays a key role in transcription of immunoglobulin k (kappa) gene in mature B-lymphoid cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: avian reticuloendotheliosis viral (v-rel) oncogene homolog A; EBP-1; MGC131774; NF KB; nf-kappa-b p65; NF-kappa-B p65delta3; NF-kappa-B transcription factor p65; NF-kB p65; NFkappaB p65; nfkb rela; NFkB-p50; NFKB1; nuclear factor; nuclear factor kappa b; nuclear factor kappa B subunit p65; nuclear factor kappaB subunit p65; nuclear factor NF-kappa-B p65 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; REL A; RelA.v1; transcription factor; unnamed protein product; v-rel avian reticuloendotheliosis viral oncogene homolog A; v-rel reticuloendotheliosis viral oncogene homolog A

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Gene Aliases: AIF3BL3; CMCU; NFkB; NFKB3; nos2; p65; p65 NF-kappa B; p65 NFkB

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UniProt ID: (Human) Q04206, (Mouse) Q04207, (Rat) Q7TQN4

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Entrez Gene ID: (Human) 5970, (Mouse) 19697, (Rat) 309165

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding enzyme binding protein kinase binding chromatin DNA binding ubiquitin protein ligase binding peptide binding phosphate ion binding identical protein binding protein homodimerization activity actinin binding histone deacetylase binding sequence-specific DNA binding NF-kappaB binding ankyrin repeat binding general transcription initiation factor binding DNA-binding transcription factor binding double-stranded DNA binding macromolecular complex binding steroid hormone binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter liver development hair follicle development defense response to tumor cell chromatin organization transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter defense response inflammatory response neuropeptide signaling pathway I-kappaB kinase/NF-kappaB signaling positive regulation of cell proliferation response to bacterium organ morphogenesis response to UV-B positive regulation of vascular endothelial growth factor production positive regulation of gene expression positive regulation of Schwann cell differentiation negative regulation of angiogenesis cytokine-mediated signaling pathway signal transduction involved in regulation of gene expression lipopolysaccharide-mediated signaling pathway positive regulation of chondrocyte differentiation response to muramyl dipeptide positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production tumor necrosis factor-mediated signaling pathway negative regulation of protein sumoylation response to cytokine toll-like receptor 4 signaling pathway intracellular signal transduction cellular response to hepatocyte growth factor stimulus response to muscle stretch NIK/NF-kappaB signaling vascular endothelial growth factor signaling pathway toll-like receptor TLR6:TLR2 signaling pathway prolactin signaling pathway macrophage activation negative regulation of protein catabolic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin receptor signaling pathway regulation of inflammatory response positive regulation of T cell receptor signaling pathway cellular response to hydrogen peroxide nucleotide-binding oligomerization domain containing 2 signaling pathway interleukin-1-mediated signaling pathway response to interleukin-1 cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to peptidoglycan cellular response to nicotine cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor postsynapse to nucleus signaling pathway antiviral innate immune response negative regulation of cytokine production involved in inflammatory response negative regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of beta-amyloid formation negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter cellular response to angiotensin positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of miRNA metabolic process negative regulation of extrinsic apoptotic signaling pathway response to ischemia response to xenobiotic stimulus response to mechanical stimulus regulation of gene expression response to lipopolysaccharide response to progesterone response to insulin response to cobalamin response to hydrogen peroxide response to amino acid response to morphine response to ethanol regulation of multicellular organismal process response to cAMP negative regulation of cytokine production cellular defense response defense response to virus cGAS/STING signaling pathway positive regulation of cytokine production involved in inflammatory response
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