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Invitrogen

Annexin A2 Polyclonal Antibody

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Annexin A2 Polyclonal Antibody

Product Details

PA5-19711

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:2,000
-

Immunocytochemistry (ICC/IF)

1-5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 150 - 250 of Human Annexin II.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.9 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10977064

Product Specific Information

Heat mediated antigen retrieval recommended prior to tissue staining.

This antibody is predicted to react with rat, sheep, cow, dog and pig based on sequence homology.

Target Information

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 33-kDa calcimedin; 33-kDa lymphocyte Ca<2+>- binding protein; 33kDa lymphocyte Ca<2+>- binding protein; 36 kDa calcium-dependent phospholipid-binding protein; 36-kDa calelectrin; annexin II; annexin-2; calpactin I heavy chain; calpactin I heavy chain (p36); calpactin I heavy polypeptide; calpactin-1 heavy chain; chromobindin 8; chromobindin-8; epididymis secretory protein Li 270; epididymis secretory sperm binding protein; lipocortin II; p36; PAP-IV; placental anticoagulant protein IV; protein I; unnamed protein product

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Gene Aliases: ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2; LPC2D; P36; PAP-IV

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UniProt ID: (Human) P07355, (Rat) Q07936, (Mouse) P07356

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Entrez Gene ID: (Human) 302, (Rat) 56611, (Mouse) 12306

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Function(s)
phosphatidylserine binding protease binding RNA binding phospholipase inhibitor activity serine-type endopeptidase inhibitor activity calcium ion binding protein binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding cytoskeletal protein binding phospholipase A2 inhibitor activity AP-3 adaptor complex binding identical protein binding S100 protein binding calcium-dependent protein binding cadherin binding involved in cell-cell adhesion phospholipid binding small GTPase binding bone sialoprotein binding actin filament binding
Process(es)
angiogenesis membrane raft assembly positive regulation of receptor recycling positive regulation of protein phosphorylation negative regulation of receptor internalization membrane budding cell adhesion cell-matrix adhesion body fluid secretion positive regulation of plasminogen activation response to activity collagen fibril organization lung development positive regulation of vesicle fusion negative regulation of low-density lipoprotein particle receptor catabolic process osteoclast development fibrinolysis mRNA transcription from RNA polymerase II promoter positive regulation of vacuole organization positive regulation by host of viral process positive regulation of transcription from RNA polymerase II promoter secretion positive regulation of fibroblast proliferation regulation of neurogenesis regulation of fibrinolysis protein localization to plasma membrane response to thyroid hormone positive regulation of viral life cycle epithelial cell apoptotic process positive regulation of low-density lipoprotein particle clearance positive regulation of receptor-mediated endocytosis involved in cholesterol transport positive regulation of exocytosis positive regulation of plasma membrane repair negative regulation of transport positive regulation of multicellular organismal process cell-cell adhesion
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