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Invitrogen

EphA4 Polyclonal Antibody

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Product Details

PA5-32754

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

6 µg/mL
-

Immunocytochemistry (ICC/IF)

1:200
-
Product Specifications

Species Reactivity

Human, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 16 amino acid peptide from internal region of human EPHA4.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

50 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2550216

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset (100%); Dog, Panda, Horse (94%); Bovine, Bat, Hamster, Elephant, Pig, Opossum, Turkey, Chicken (88%); Mouse, Rat, Rabbit, Platypus, Lizard, Xenopus (81%).

For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

EPHA4 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EphA4 encodes a protein that binds ephrin-A ligands.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EK8; epa4; EPH-like kinase 8; Ephrin type-A receptor 4; receptor protein-tyrosine kinase HEK8; TYRO1 protein tyrosine kinase; Tyrosine-protein kinase receptor SEK; Tyrosine-protein kinase TYRO1; unnamed protein product

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Gene Aliases: EK8; EPHA4; HEK8; SEK; TYRO1

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UniProt ID: (Human) P54764

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Entrez Gene ID: (Human) 2043

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Function(s)
nucleotide binding beta-amyloid binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity GPI-linked ephrin receptor activity transmembrane-ephrin receptor activity protein binding ATP binding kinase activity transferase activity PH domain binding identical protein binding ephrin receptor binding DH domain binding protein tyrosine kinase binding
Process(es)
deadenylation-dependent decapping of nuclear-transcribed mRNA cell adhesion negative regulation of cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway nervous system development axon guidance adult walking behavior motor neuron axon guidance positive regulation of cell proliferation glial cell migration negative regulation of epithelial to mesenchymal transition negative regulation of neuron projection development negative regulation of translation corticospinal tract morphogenesis positive regulation of cell migration negative regulation of cell migration adherens junction organization regulation of GTPase activity negative regulation of neuron apoptotic process positive regulation of cell adhesion negative regulation of translational initiation positive regulation of JNK cascade ephrin receptor signaling pathway negative regulation of axon regeneration regulation of astrocyte differentiation regulation of axonogenesis positive regulation of dendrite morphogenesis protein stabilization innervation regulation of dendritic spine morphogenesis negative regulation of ERK1 and ERK2 cascade nephric duct morphogenesis cochlea development fasciculation of sensory neuron axon fasciculation of motor neuron axon neuron projection guidance synapse pruning neuron projection fasciculation membraneless organelle assembly negative regulation of cellular response to hypoxia negative regulation of long-term synaptic potentiation positive regulation of beta-amyloid formation positive regulation of intracellular signal transduction positive regulation of amyloid precursor protein catabolic process negative regulation of proteolysis involved in cellular protein catabolic process cellular response to beta-amyloid regulation of modification of synaptic structure regulation of synapse pruning
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