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Invitrogen
HELT Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-48608
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 131-160 amino acids from the Central region of human HELT.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.45 mg/mL
Amount
180 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with zebrafish based on sequence homology.
Target Information
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLH transcription factor megane; Hes-like transcription factor; HES/HEY-like transcription factor; Hey-like transcription factor; Hey-like transcriptional repressor; Megane bHLH factor; mesencephalic GABAergic neurons enhancer of split related protein; protein megane; unnamed protein product
Gene Aliases: A830086M02; bHLHb44; HCM1228; HESL; Heslike; megane; Mgn
UniProt ID: (Human) A6NFD8, (Mouse) Q7TS99
Entrez Gene ID: (Human) 391723, (Mouse) 234219
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
identical protein binding
protein dimerization activity
protein binding
negative regulation of transcription from RNA polymerase II promoter
suckling behavior
regulation of transcription, DNA-templated
Notch signaling pathway
central nervous system development
post-embryonic development
anterior/posterior pattern specification
gene expression
GABAergic neuron differentiation in basal ganglia
neuron differentiation
multicellular organism growth
positive regulation of transcription from RNA polymerase II promoter
regulation of neurogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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