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Invitrogen

Substance P Polyclonal Antibody

View all (4) Substance P antibodies

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Product Details

PA5-75165

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to mature of Substance P of human origin.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2718893

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).

Target Information

Substance P (SP) is currently thought to be one of the most important neurotransmitters and neurotransmitters in the brain. It is an undecapeptide belonging to the tachykinin family, which consists of excitatory neuropeptides synthesised in neuronal and glial cells of the human central and peripheral nervous system. Substance P, Neurokinin A, Neuropeptide K, and Neuropeptide gamma are all generated by post-translation cleavage of the precursor Protachykinin-1. Substance P forms the major endogenous ligand for Neurokinin 1 Receptor. The pharmacology of Substance P has been associated with a number of neurological and psychiatric disorders, namely nociception, migraine, asthma, nausea, inflammatory bowel syndrome, urinary incontinence, anxiety and depression. It has also been linked to obesity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: beta-preprotachykinin; gamma-preprotachykinin A; MGC26719; neurokinin 1; neurokinin 2; neurokinin A; neurokinin alpha; neuromedin L; neuropeptide gamma; neuropeptide K; PPT; precursor 1; preprotachykinin; preprotachykinin A; protachykinin; RAT TAC; substance K; substance P; TAC1; Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma); tachykinin 1; tachykinin 2; tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)

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Gene Aliases: 4930528L02Rik; Hs.2563; NK-1; NK1; NK2; NKNA; NPK; PPT-A; Ppt5fl; PPTA; PPTA3; RATPPTA3; SP; TAC; TAC2

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UniProt ID: (Human) P20366, (Rat) P06767, (Mouse) P41539

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Entrez Gene ID: (Human) 6863, (Rat) 24806, (Mouse) 21333

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Function(s)
neuropeptide hormone activity protein binding substance P receptor binding neuromedin K receptor binding substance K receptor binding receptor agonist activity neuropeptide activity
Process(es)
positive regulation of acute inflammatory response negative regulation of systemic arterial blood pressure inflammatory response G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration phospholipase C-activating tachykinin receptor signaling pathway tachykinin receptor signaling pathway long-term memory regulation of blood pressure associative learning response to hormone negative regulation of heart rate positive regulation of epithelial cell migration sensory perception of pain positive regulation of synaptic transmission, cholinergic positive regulation of synaptic transmission, GABAergic response to lipopolysaccharide positive regulation of mast cell degranulation innate immune response positive regulation of action potential positive regulation of ossification response to pain positive regulation of lymphocyte proliferation detection of temperature stimulus involved in sensory perception of pain positive regulation of stress fiber assembly regulation of sensory perception of pain antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of sperm motility positive regulation of sensory perception of pain cellular response to nerve growth factor stimulus positive regulation of corticosterone secretion response to yeast antibacterial humoral response antifungal humoral response killing of cells of other organism defense response to Gram-negative bacterium defense response to Gram-positive bacterium cell-cell signaling insemination detection of abiotic stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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