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Invitrogen
ABCD1 Polyclonal Antibody
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FIGURE: 1 / 2
ABCD1 Antibody (PA5-80291) in ICC/IF
Immunofluorescence staining of ABCD1 in MCF7 cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with ABCD1 Polyclonal Antibody (Product # PA5-80291, 1:500) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to cytoplasm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-80291
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the center region of the Human ABCD1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7
Contains
0.03% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody has specificity for Human ABCD1.
Target Information
This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adrenoleukodystrophy protein; ATP-binding cassette, sub-family D (ALD), member 1
Gene Aliases: ABC42; ALD; ALDP; AMN
UniProt ID: (Human) P33897
Entrez Gene ID: (Human) 215
long-chain fatty acid transporter activity
protein binding
ATP binding
ABC-type fatty-acyl-CoA transporter activity
ATPase activity
enzyme binding
ATPase activity, coupled to transmembrane movement of substances
identical protein binding
protein homodimerization activity
ADP binding
acyl-CoA hydrolase activity
long-chain acyl-CoA hydrolase activity
very long chain acyl-CoA hydrolase activity
ABC-type transporter activity
very long-chain fatty acid metabolic process
regulation of oxidative phosphorylation
fatty acid biosynthetic process
fatty acid beta-oxidation
peroxisome organization
peroxisomal long-chain fatty acid import
fatty-acyl-CoA transport
peroxisomal membrane transport
regulation of fatty acid metabolic process
fatty acid elongation
regulation of fatty acid beta-oxidation
positive regulation of fatty acid beta-oxidation
alpha-linolenic acid metabolic process
very long-chain fatty-acyl-CoA catabolic process
long-chain fatty acid catabolic process
very long-chain fatty acid catabolic process
myelin maintenance
linoleic acid metabolic process
positive regulation of lipid metabolic process
regulation of mitochondrial depolarization
transmembrane transport
fatty acid homeostasis
sterol homeostasis
negative regulation of cytokine production involved in inflammatory response
regulation of cellular response to oxidative stress
negative regulation of reactive oxygen species biosynthetic process
neuron projection maintenance
positive regulation of unsaturated fatty acid biosynthetic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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