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Invitrogen
beta-2 Microglobulin Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-81587
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Rat B2M/beta-2 microglobulin protein (Met1-Met119)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
5 mg/mL
Amount
500 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Rat B2M/beta-2 microglobulin.
Target Information
Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-F; B2-microglobulin; Beta 2 microglobin; Beta 2 microglobulin; beta-2-microglobulin C-terminal fragment (55 AA); Beta2 microglobulin; MHC Class I; microglobulin beta-2; Orla-B2m; unnamed protein product
UniProt ID: (Rat) P07151
Entrez Gene ID: (Rat) 24223
positive regulation of T cell mediated cytotoxicity
response to molecule of bacterial origin
antigen processing and presentation of exogenous peptide antigen via MHC class Ib
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
peptide antigen assembly with MHC class I protein complex
peptide antigen assembly with MHC class II protein complex
positive regulation of T cell cytokine production
regulation of membrane depolarization
iron ion transport
cellular iron ion homeostasis
immune response
sensory perception of smell
learning or memory
response to xenobiotic stimulus
response to metal ion
negative regulation of neuron projection development
antigen processing and presentation of endogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class II
T cell differentiation in thymus
transferrin transport
regulation of iron ion transport
negative regulation of iron ion transport
protein refolding
innate immune response
regulation of erythrocyte differentiation
response to cadmium ion
positive regulation of receptor-mediated endocytosis
negative regulation of receptor-mediated endocytosis
negative regulation of epithelial cell proliferation
negative regulation of neurogenesis
positive regulation of immune response
positive regulation of T cell activation
protein homotetramerization
multicellular organismal iron ion homeostasis
antimicrobial humoral immune response mediated by antimicrobial peptide
cellular response to lipopolysaccharide
cellular response to iron ion
cellular response to iron(III) ion
cellular response to nicotine
amyloid fibril formation
positive regulation of cellular senescence
negative regulation of forebrain neuron differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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