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Invitrogen
Arp2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-96410
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human Arp2 (NP_0057131)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MDSQGRKVVV CDNGTGFVKC GYAGSNFPEH IFPALVGRPI IRSTTKVGNI EIKDLMVGDE ASELRSMLEV NYPMENGIVR NWDDMKHLWD YTFGPEKLNI DTRNCKILLT EPPMNPTKNR EKIVEVMFET YQFSGVYVAI QAVLTLYAQG LLTGVVVDSG; Positive Samples: THP-1, 293T, HepG2, HeLa, C6, Mouse spleen, Mouse lung, Mouse brain, Rat kidney; Cellular Location: Cell projection, Cytoplasm, cytoskeleton
Target Information
ARP2 (actin-related protein 2) is an ATP-binding component of the ARP2/3 complex - a multiprotein complex that mediates actin polymerization upon stimulation by the nucleation-promoting factor (NPF). The ARP2/3 complex mediates the formation of branched actin networks in the cytoplasm and provides the force for cell motility. The ARP2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actin-like protein 2; ARP2 actin related protein 2 homolog; ARP2 actin-related protein 2 homolog; one of seven subunits of the Arp2/3 protein complex; unnamed protein product
Gene Aliases: 4921510D23Rik; ARP2; D6Ertd746e
UniProt ID: (Human) P61160, (Mouse) P61161, (Rat) Q5M7U6
Entrez Gene ID: (Human) 10097, (Mouse) 66713, (Rat) 289820
positive regulation of lamellipodium assembly
Arp2/3 complex-mediated actin nucleation
positive regulation of transcription from RNA polymerase II promoter
cilium morphogenesis
positive regulation of double-strand break repair via homologous recombination
regulation of double-strand break repair via nonhomologous end joining
establishment or maintenance of cell polarity
asymmetric cell division
meiotic chromosome movement towards spindle pole
cytosolic transport
actin cytoskeleton organization
meiotic cytokinesis
meiotic cell cycle
spindle localization
positive regulation of dendritic spine morphogenesis
cellular response to interferon-gamma
associative learning
response to immobilization stress
cellular response to trichostatin A
response to ethanol
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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