Gibco™

Soluble TNF-RII Recombinant Human Protein

Catalog number:  PHR3025

Related applications:

Cell Viability, Proliferation & Function

| Mammalian Cell Culture

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Description

Recombinant Soluble TNF-RII is a bioactive protein intended for use in cell culture applications. sTNF-RII is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Endotoxin Level: < 0.1 ng/µg
Form: Lyophilized
Mass: 20 µg
Product Line: Gibco®
Protein Form: Recombinant, Ligand
Research Category: Immunology, Inflammation, Oncology, Signal Transduction
Shipping Condition: Approved for shipment on Wet or Dry Ice
Species: Human
Gene ID (Entrez): 7133
Molecular Weight: 18.9 kDa
Purification Method: Sequential Chromatography
Purity: 98 %
Protein Subtype: TNF (Tumor Necrosis Factor)
Gene Alias: Soluble TNF-RII
Validated Application: Cell Culture
Protein Family: Cytokines & Receptors
Expression System: E. coli

Contents & storage

Store in freezer (-5 to -30°C).