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Thermo Scientific™

EGFR (ErbB1) [L858R] Recombinant Human Protein

Catalog number:  PV4128

Related applications:

Protein Assays and Analysis

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Description

The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The EGFR L858R mutation is implicated in epithelial tumor formation.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_005219.2; L858R
Assay Entry: Biochemical binding/kinetic, Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity
Kinase Group: Tyrosine Kinases
Shipping Condition: Dry Ice
System Compatibility: LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™, Omnia® Bulk Substrate
Target Entry: EGFR L858R
Target Gene: Epidermal growth factor receptor
Expression System: Baculovirus
Protein Family: Kinases & Inhibitors
Protein Form: Recombinant, Cytoplasmic
Protein Subtype: Receptor Tyrosine Kinases
Research Category: Oncology, Signal Transduction
Species: Human
Validated Application: Kinase Assay
Gene ID (Entrez): 1956, 7124
Molecular Weight: 90.5 kDa
Gene Alias: EGFR (ErbB1) L858R
KinaseFamily: EGF Receptor (ErbB) Kinase Family
Protein Length: aa 668-1210: L858R
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% Glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.