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Thermo Scientific™

JAK2 [V617F] Recombinant Human Protein, JH1 and JH2 Domains

Catalog number:  PV4336

Related applications:

Protein Assays and Analysis

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Description

JAK2 is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. This kinase contains both the JH1 (catalytic) and JH2 (pseudokinase) domains of JAK2. The V617F mutation has been shown to be a cause of polycythemia vera.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_004963
Assay Entry: Biochemical terbium phospho-specific activity, Biochemical phospho-specific activity (no antibody)
Kinase Group: Tyrosine Kinases
Shipping Condition: Dry Ice
System Compatibility: LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™, Omnia® Bulk Substrate
Target Entry: JAK2 JH1 JH2 V617F
Target Gene: Janus kinase 2
Expression System: Baculovirus
Protein Family: Kinases & Inhibitors
Protein Form: Recombinant, Cytoplasmic, Catalytic
Protein Subtype: Cytoplasmic Tyrosine Kinases
Research Category: Signal Transduction
Species: Human
Validated Application: Kinase Assay
Gene ID (Entrez): 3717
Molecular Weight: 97.9 kDa
Gene Alias: JAK2 JH1 JH2 V617F
KinaseFamily: JAK Kinase Family
Protein Length: aa 532-1132; V617F
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.