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NeoBiotechnologies
Actin, Muscle Specific (Muscle Cell Marker) Recombinant Rabbit Monoclonal Antibody (MSA/8949R)
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Product Details
RBM6-8949-P0
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
MSA/8949R
Immunogen
Recombinant protein corresponding to human muscle actin
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Amount
20 µg
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control:Muscle or sarcoma.
Cellular Location: Cytoplasm.
Target Information
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACTA1; ACTA2; ACTC; ACTG2; actin, alpha 2, smooth muscle, aorta; actin, gamma 2, smooth muscle, enteric; actin-like protein; alpha-actin; alpha-actin-3; alpha-cardiac actin; alpha-sma; cell growth-inhibiting gene 46 protein; cytoskeletal gamma-actin; epididymis luminal protein 176; gamma-actin; GIG46; nemaline myopathy type 3; RP5-1068B5.2; unnamed protein product
Gene Aliases: ACT; ACTA; ACTA3; ACTC; ACTE; ACTG; ACTL3; ACTSA; ACTSG; ASD5; ASMA; CFTD; CFTD1; CFTDM; CMD1R; CMH11; CMYO2A; CMYO2B; CMYO2C; CMYP2A; CMYP2B; CMYP2C; DFNA20; DFNA26; HEL-176; LVNC4; MMIHS5; MPFD; NEM1; NEM2; NEM3; SHPM; SMDYS; VSCM; VSCM1
UniProt ID: (Human) P68133, (Human) P62736, (Human) P68032, (Human) P63261, (Human) P63267
Entrez Gene ID: (Human) 58, (Human) 59, (Human) 70, (Human) 71, (Human) 72
actin filament organization
positive regulation of gene expression
actin filament-based movement
skeletal muscle thin filament assembly
actomyosin structure organization
actin-myosin filament sliding
cardiac myofibril assembly
cardiac muscle tissue morphogenesis
heart contraction
mesenchyme migration
angiogenesis
morphogenesis of a polarized epithelium
cytoskeleton organization
axonogenesis
positive regulation of cell migration
maintenance of blood-brain barrier
cell motility
regulation of stress fiber assembly
regulation of focal adhesion assembly
platelet aggregation
positive regulation of wound healing
postsynaptic actin cytoskeleton organization
tight junction assembly
regulation of transepithelial transport
regulation of synaptic vesicle endocytosis
protein localization to bicellular tight junction
response to ethanol
cellular response to interleukin-6
cellular response to acetaldehyde
muscle contraction
skeletal muscle fiber development
response to virus
positive regulation of hepatic stellate cell migration
positive regulation of hepatic stellate cell contraction
positive regulation of ERK1 and ERK2 cascade
cellular response to transforming growth factor beta stimulus
juxtaglomerular apparatus development
glomerular mesangial cell development
positive regulation of hepatic stellate cell activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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