p53 Monoclonal Antibody (OTI5D9), TrueMAB™

transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding TFIID-class transcription factor binding transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protease binding p53 binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding mRNA 3'-UTR binding copper ion binding protein binding zinc ion binding enzyme binding receptor tyrosine kinase binding ubiquitin protein ligase binding histone deacetylase regulator activity annealing helicase activity identical protein binding histone deacetylase binding metal ion binding protein heterodimerization activity chaperone binding protein phosphatase 2A binding RNA polymerase II sequence-specific DNA binding transcription factor binding 14-3-3 protein binding MDM2/MDM4 family protein binding disordered domain specific binding general transcription initiation factor binding molecular function activator activity molecular condensate scaffold activity promoter-specific chromatin binding

negative regulation of transcription from RNA polymerase II promoter mitophagy in utero embryonic development somitogenesis release of cytochrome c from mitochondria hematopoietic progenitor cell differentiation T cell proliferation involved in immune response B cell lineage commitment T cell lineage commitment response to ischemia nucleotide-excision repair double-strand break repair regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein import into nucleus autophagy apoptotic process cellular response to DNA damage stimulus response to oxidative stress ER overload response transforming growth factor beta receptor signaling pathway Ras protein signal transduction regulation of mitotic cell cycle gastrulation neuroblast proliferation negative regulation of neuroblast proliferation central nervous system development heart development circadian rhythm protein localization negative regulation of DNA replication cell proliferation negative regulation of cell proliferation determination of adult lifespan mRNA transcription rRNA transcription response to xenobiotic stimulus response to UV response to salt stress embryo development ending in birth or egg hatching response to X-ray response to ionizing radiation response to gamma radiation positive regulation of gene expression negative regulation of gene expression cardiac muscle cell apoptotic process positive regulation of cardiac muscle cell apoptotic process programmed cell death glial cell proliferation viral process glucose catabolic process to lactate via pyruvate cerebellum development negative regulation of cell growth DNA damage response, signal transduction by p53 class mediator negative regulation of transforming growth factor beta receptor signaling pathway mitotic G1 DNA damage checkpoint negative regulation of telomere maintenance via telomerase T cell differentiation in thymus tumor necrosis factor-mediated signaling pathway cellular response to stress regulation of tissue remodeling cellular response to UV multicellular organism growth positive regulation of mitochondrial membrane permeability regulation of cell proliferation cellular response to glucose starvation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process entrainment of circadian clock by photoperiod mitochondrial DNA repair regulation of DNA damage response, signal transduction by p53 class mediator regulation of neuron apoptotic process positive regulation of neuron apoptotic process positive regulation of gene expression, epigenetic negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of RNA polymerase II transcriptional preinitiation complex assembly negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter response to antibiotic fibroblast proliferation negative regulation of fibroblast proliferation rhythmic process circadian behavior bone marrow development embryonic organ development protein stabilization negative regulation of DNA metabolic process negative regulation of helicase activity protein tetramerization chromosome organization neuron apoptotic process regulation of cell cycle hematopoietic stem cell differentiation negative regulation of glial cell proliferation interferon-gamma-mediated signaling pathway cardiac septum morphogenesis positive regulation of programmed necrotic cell death protein-containing complex assembly intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress thymocyte apoptotic process regulation of thymocyte apoptotic process positive regulation of thymocyte apoptotic process necroptotic process cellular response to hypoxia cellular response to xenobiotic stimulus cellular response to ionizing radiation cellular response to gamma radiation cellular response to UV-C stem cell proliferation signal transduction by p53 class mediator intrinsic apoptotic signaling pathway by p53 class mediator reactive oxygen species metabolic process cellular response to actinomycin D positive regulation of release of cytochrome c from mitochondria cellular senescence replicative senescence oxidative stress-induced premature senescence apoptotic signaling pathway intrinsic apoptotic signaling pathway oligodendrocyte apoptotic process positive regulation of execution phase of apoptosis negative regulation of macromitophagy regulation of mitochondrial membrane permeability involved in apoptotic process regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of cell cycle G2/M phase transition positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of G1 to G0 transition negative regulation of production of miRNAs involved in gene silencing by miRNA negative regulation of glucose catabolic process to lactate via pyruvate negative regulation of pentose-phosphate shunt intrinsic apoptotic signaling pathway in response to hypoxia regulation of fibroblast apoptotic process negative regulation of reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process negative regulation of stem cell proliferation regulation of cellular senescence positive regulation of cellular senescence regulation of intrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway